Cadinane sesquiterpenoids isolated from Santalum album using a screening program for Wnt signal inhibitory activity
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DOI: 10.1007/s11418-019-01380-x
Abstract: Upon screening compounds having Wnt signal inhibitory activity through evaluating TCF/β-catenin transcriptional (TOP) activity, eight cadinane sesquiterpenoids, including three new compounds (1–3), were isolated from wood extracts of Santalum album (Santalaceae). Structures of compounds 1–3… read more here.
Keywords: signal inhibitory; cadinane sesquiterpenoids; cadinane; wnt signal ... See more keywords
Abstract LB-099: Prostate cancer-secreted CCN3/NOV promotes osteoblast differentiation via Wnt signal pathway and miR-608 suppression
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DOI: 10.1158/1538-7445.sabcs18-lb-099
Abstract: Objective: NOV/CCN3 is a secreted protein that interacts with the extracellular matrix and thereby regulates many cellular functions, including cell division, chemotaxis, apoptosis, adhesion, motility, and ion transport. Recently, CCN3 expression have been implicated in… read more here.
Keywords: differentiation; wnt signal; pca; cancer ... See more keywords