Magnetic Mechanoactivation of Wnt Signaling Augments Dopaminergic Differentiation of Neuronal Cells
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DOI: 10.1002/adbi.201900091
Abstract: Wnt signaling is a key developmental pathway that regulates dopaminergic progenitor cell proliferation and differentiation during neuronal development. This makes Wnt signaling an important therapeutic target for neurodegenerative conditions such as Parkinson's disease. Wnt signaling… read more here.
Keywords: wnt signaling; wnt; magnetic mechanoactivation; differentiation neuronal ... See more keywords
Cytoplasmic NEAT1 Suppresses AML Stem Cell Self-Renewal and Leukemogenesis through Inactivation of Wnt Signaling.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced science"
DOI: 10.1002/advs.202100914
Abstract: As an essential component of paraspeckles, nuclear paraspeckle assembly transcript 1 (NEAT1) localizes in the nucleus, promoting progression of various malignant solid tumors. Herein, an adverse effect of NEAT1 is reported, showing that the short… read more here.
Keywords: suppresses aml; wnt signaling; stem; cytoplasmic neat1 ... See more keywords
Small Molecules Inspired by the Natural Product Withanolides as Potent Inhibitors of Wnt Signaling
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DOI: 10.1002/cbic.201700260
Abstract: Wnt signaling is a fundamental pathway that drives embryonic development and is essential for stem cell maintenance and tissue homeostasis. Dysregulation of Wnt signaling is linked to various diseases, and a constitutively active Wnt pathway… read more here.
Keywords: wnt signaling; small molecules; inhibitors wnt; natural product ... See more keywords
Exosomes‐mediated transfer of long noncoding RNA LINC01133 represses bladder cancer progression via regulating the Wnt signaling pathway
Sign Up to like & getrecommendations! Published in 2021 at "Cell Biology International"
DOI: 10.1002/cbin.11590
Abstract: Bladder cancer (BC), as one of the most common malignant cancers of the urinary system, has a high incidence and mortality rates. Recently, increasing studies have indicated that exosomes can mediate cellular communication in assorted… read more here.
Keywords: bladder cancer; long noncoding; wnt signaling; linc01133 ... See more keywords
Triptolide inhibits Wnt signaling in NSCLC through upregulation of multiple Wnt inhibitory factors via epigenetic modifications to Histone H3
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Cancer"
DOI: 10.1002/ijc.31756
Abstract: In the last decade, it has become clear that epigenetic changes act together with genetic mutations to promote virtually every stage of tumorigenesis and cancer progression. This knowledge has triggered searches for “epigenetic drugs” that… read more here.
Keywords: wnt signaling; epigenetic modifications; wnt inhibitory; epigenetic changes ... See more keywords
MiR 376c inhibits osteoblastogenesis by targeting Wnt3 and ARF‐GEF‐1 ‐facilitated augmentation of beta‐catenin transactivation
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26490
Abstract: Wnt signaling pathway plays important role in all aspects of skeletal development which include chondrogenesis, osteoblastogenesis, and osteoclastogenesis. Induction of the Wnt‐3 signaling pathway promotes bone formation while inactivation of the pathway leads to bone… read more here.
Keywords: wnt signaling; 376c inhibits; catenin transactivation; arf gef ... See more keywords
PlGF knockdown induced apoptosis through Wnt signaling pathway in gastric cancer stem cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27593
Abstract: Despite the fact that much research has focused on gastric cancer, it is still a worldwide concern, because of the difficulties with factors such as signaling pathway crosstalk and gastric cancer stem cell (GCSC). Placental… read more here.
Keywords: wnt signaling; apoptosis; gastric cancer; signaling pathway ... See more keywords
Overexpression of LINC00261 inhibits non–small cell lung cancer cells progression by interacting with miR‐522‐3p and suppressing Wnt signaling
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29149
Abstract: Long noncoding RNA LINC00261 has been experimentally validated to function as a tumor suppressor in several cancers, but its pathological role and functional mechanism in non–small cell lung cancer (NSCLC) are largely unclear. In this… read more here.
Keywords: overexpression; wnt signaling; linc00261; cancer ... See more keywords
SNHG1/miR‐556‐5p/TCF12 feedback loop enhances the tumorigenesis of meningioma through Wnt signaling pathway
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29423
Abstract: Meningioma, as a sort of the malignantly intracranial tumors, has captured public attention for its second‐highest morbidity all over the world. Long noncoding RNAs (lncRNAs), including lncRNA SNHG1, have been well known as essential players… read more here.
Keywords: wnt signaling; mir 556; signaling pathway; meningioma ... See more keywords
Downregulation of long noncoding RNA DGCR5 contributes to the proliferation, migration, and invasion of cervical cancer by activating Wnt signaling pathway
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27825
Abstract: Accumulating research works have reported that long noncoding RNAs (lncRNAs) are involved in various cancers, including cervical cancer. LncRNA DGCR5 has been identified in many cancers. However, the biological role of DGCR5 in cervical cancer… read more here.
Keywords: long noncoding; wnt signaling; dgcr5; cervical cancer ... See more keywords
Wnt signaling associated small molecules improve the viability of pPSCs in a PI3K/Akt pathway dependent way
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29514
Abstract: Although we have obtained porcine pluripotent stem cell lines (pPSCs) from blastocysts, the cells exhibit flat clonal morphology and do not support single‐cell passage. There is massive cell death after cell dissociation, and the efficiency… read more here.
Keywords: ppscs; wnt signaling; signaling associated; viability ... See more keywords