WNT Signalling in Lung Physiology and Pathology.
Sign Up to like & getrecommendations! Published in 2021 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2021_521
Abstract: The main physiological function of the lung is gas exchange, mediated at the interface between the alveoli and the pulmonary microcapillary network and facilitated by conducting airway structures that regulate the transport of these gases… read more here.
Keywords: pathology; physiology; wnt signalling; lung diseases ... See more keywords
Wnt Signalling-Targeted Therapy in the CMS2 Tumour Subtype: A New Paradigm in CRC Treatment?
Sign Up to like & getrecommendations! Published in 2018 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-02771-1_6
Abstract: Colorectal cancers (CRC) belonging to the consensus molecular subtype 2 (CMS2) have the highest incidence rate, affect mainly the distal colon and rectum, and are characterized by marked Wnt/β-catenin/Transcription Factor 7-Like 2 (TCF7L2) pathway activation… read more here.
Keywords: cms2; wnt; treatment; wnt signalling ... See more keywords
Wnt signalling pathway in bladder cancer.
Sign Up to like & getrecommendations! Published in 2020 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2020.109886
Abstract: Bladder cancer (BC) is one of the most common tumours of the urinary system and is also known as a highly malignant tumour. In addition to conventional diagnosis and treatment methods, recent research has focused… read more here.
Keywords: bladder cancer; signalling pathway; wnt signalling; pathway bladder ... See more keywords
Loss-of-function mutations in Carboxypeptidase D cause a new syndrome with lymphedema and sensorineural hearing loss
Sign Up to like & getrecommendations! Published in 2017 at "Mechanisms of Development"
DOI: 10.1016/j.mod.2017.04.033
Abstract: tween long bones. It is molecularly, morphologically and histologically distinct from transient cartilage, the embryonic cartilage that is eventually replaced by bone. Ray et al., in their recent study, have proposed a model for concomitant… read more here.
Keywords: cartilage differentiation; articular cartilage; wnt signalling; cartilage ... See more keywords
Expanding the ciliopathy spectrum
Sign Up to like & getrecommendations! Published in 2017 at "Mechanisms of Development"
DOI: 10.1016/j.mod.2017.04.035
Abstract: tween long bones. It is molecularly, morphologically and histologically distinct from transient cartilage, the embryonic cartilage that is eventually replaced by bone. Ray et al., in their recent study, have proposed a model for concomitant… read more here.
Keywords: cartilage differentiation; articular cartilage; study; wnt signalling ... See more keywords
Controlled functional zonation of hepatocytes in vitro by engineering of Wnt signalling.
Sign Up to like & getrecommendations! Published in 2020 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.9b00435
Abstract: Key liver functions including protein synthesis, carbohydrate metabolism and detoxification are performed by specific populations of hepatocytes which are defined by their relative position within the liver lobules. On a molecular level, the functional heterogeneity… read more here.
Keywords: controlled functional; functional zonation; wnt signalling; zonation ... See more keywords
Intracellular pH controls WNT downstream of glycolysis in amniote embryos
Sign Up to like & getrecommendations! Published in 2020 at "Nature"
DOI: 10.1038/s41586-020-2428-0
Abstract: Formation of the body of vertebrate embryos proceeds sequentially by posterior addition of tissues from the tail bud. Cells of the tail bud and the posterior presomitic mesoderm, which control posterior elongation 1 , exhibit… read more here.
Keywords: bud; glycolysis; tail bud; wnt signalling ... See more keywords
Membrane capacitance recordings resolve dynamics and complexity of receptor-mediated endocytosis in Wnt signalling
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-49082-4
Abstract: Receptor-mediated endocytosis is an essential process in signalling pathways for activation of intracellular signalling cascades. One example is the Wnt signalling pathway that seems to depend on endocytosis of the ligand-receptor complex for initiation of… read more here.
Keywords: capacitance recordings; endocytosis; mediated endocytosis; wnt signalling ... See more keywords
WNK regulates Wnt signalling and β-Catenin levels by interfering with the interaction between β-Catenin and GID
Sign Up to like & getrecommendations! Published in 2020 at "Communications Biology"
DOI: 10.1038/s42003-020-01386-2
Abstract: β-Catenin is an important component of the Wnt signalling pathway. As dysregulation or mutation of this pathway causes many diseases, including cancer, the β-Catenin level is carefully regulated by the destruction complex in the Wnt… read more here.
Keywords: wnk regulates; catenin; wnt signalling; interaction catenin ... See more keywords
WNT signalling in the normal human adult testis and in male germ cell neoplasms.
Sign Up to like & getrecommendations! Published in 2020 at "Human reproduction"
DOI: 10.1093/humrep/deaa150
Abstract: STUDY QUESTION Is WNT signalling functional in normal and/or neoplastic human male germ cells? SUMMARY ANSWER Regulated WNT signalling component synthesis in human testes indicates that WNT pathway function changes during normal spermatogenesis and is… read more here.
Keywords: testis; wnt signalling; cell; germ cell ... See more keywords
Rationale for targeting the Wnt signalling modulator Dickkopf‐1 for oncology
Sign Up to like & getrecommendations! Published in 2017 at "British Journal of Pharmacology"
DOI: 10.1111/bph.13894
Abstract: Wnt signalling is a fundamental pathway involved in embryonic development and adult tissue homeostasis. Mutations in the pathway frequently lead to developmental defects and cancer. As such, therapeutic intervention of this pathway has generated tremendous… read more here.
Keywords: targeting wnt; rationale targeting; dickkopf; wnt signalling ... See more keywords