Wnt11 regulates cardiac chamber development and disease during perinatal maturation.
Sign Up to like & getrecommendations! Published in 2017 at "JCI insight"
DOI: 10.1172/jci.insight.94904
Abstract: Ventricular chamber growth and development during perinatal circulatory transition is critical for functional adaptation of the heart. However, the chamber-specific programs of neonatal heart growth are poorly understood. We used integrated systems genomic and functional… read more here.
Keywords: chamber; heart; wnt11; proliferation ... See more keywords
Wnt11 directs nephron progenitor polarity and motile behavior ultimately determining nephron endowment
Sign Up to like & getrecommendations! Published in 2018 at "eLife"
DOI: 10.7554/elife.40392
Abstract: A normal endowment of nephrons in the mammalian kidney requires a balance of nephron progenitor self-renewal and differentiation throughout development. Here, we provide evidence for a novel action of ureteric branch tip-derived Wnt11 in progenitor… read more here.
Keywords: determining nephron; wnt11; ultimately determining; nephron progenitor ... See more keywords