Global gene expression analysis identifies Mef2c as a potential player in Wnt16-mediated transcriptional regulation.
Sign Up to like & getrecommendations! Published in 2018 at "Gene"
DOI: 10.1016/j.gene.2018.06.079
Abstract: Wnt16 is a major Wnt ligand involved in the regulation of postnatal bone homeostasis. Previous studies have shown that Wnt16 promotes bone formation and inhibits bone resorption, suggesting that this molecule could be targeted for… read more here.
Keywords: wnt16 mediated; gene expression; gene; wnt16 ... See more keywords
wnt16 regulates spine and muscle morphogenesis through parallel signals from notochord and dermomyotome
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DOI: 10.1371/journal.pgen.1010496
Abstract: Bone and muscle interact through developmental, mechanical, paracrine, and autocrine signals. Genetic variants at the CPED1-WNT16 locus are dually associated with bone- and muscle-related traits. While Wnt16 is necessary for bone mass and strength, this… read more here.
Keywords: wnt16; spine muscle; genetic variants; bone muscle ... See more keywords
Induced inactivation of Wnt16 in young adult mice has no impact on osteoarthritis development
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DOI: 10.1371/journal.pone.0277495
Abstract: Osteoarthritis (OA) is a common disorder and a major cause of disability in the elderly population. WNT16 has been suggested to play important roles in joint formation, bone homeostasis and OA development, but the mechanism… read more here.
Keywords: cre wnt16flox; wnt16; flox mice; wnt16flox flox ... See more keywords
Wnt16 signaling in bone homeostasis and osteoarthristis
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DOI: 10.3389/fendo.2022.1095711
Abstract: Wnts are secreted cysteine-rich glycoproteins involved in joint development and skeletal homeostasis and have been implicated in the occurrence of osteoarthritis. Over the past decade, Wnt16, a member of the Wnt family, has received widespread… read more here.
Keywords: wnt16; bone; osteoarthritis; wnt16 signaling ... See more keywords
Wnt16 signaling promotes osteoblast differentiation of periosteal derived cells in vitro and in vivo
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DOI: 10.7717/peerj.10374
Abstract: Background Periosteum plays critical roles in de novo bone formation and fracture repair. Wnt16 has been regarded as a key regulator in periosteum bone formation. However, the role of Wnt16 in periosteum derived cells (PDCs)… read more here.
Keywords: bone; expression; mrna expression; differentiation ... See more keywords