The angiotensin-converting enzyme inhibitor, captopril, suppressed Hepatic Stellate Cell activation via NF-kappaB or wnt3α/β-catenin pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Bioengineered"
DOI: 10.1080/21655979.2021.1987091
Abstract: Activation of hepatic stellate cells (HSC) is associated with hepatic fibrogenesis, which is one of complications of diabetes mellitus. Captopril possesses potent anti-inflammation, oxidative stress and fibrosis effects. However, the specific molecular mechanism of captopril… read more here.
Keywords: wnt3 catenin; kappab wnt3; captopril; cell ... See more keywords
Inhibition of RIP1-RIP3-mediated necroptosis attenuates renal fibrosis via Wnt3α/β-catenin/GSK-3β signaling in unilateral ureteral obstruction
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DOI: 10.1371/journal.pone.0274116
Abstract: Renal fibrosis represents the final common outcome of chronic kidney disease of virtually any etiology. However, the mechanism underlying the evolution of renal fibrosis remains to be addressed. This study sought to clarify whether RIP1-RIP3-mediated… read more here.
Keywords: catenin gsk; gsk signaling; renal fibrosis; wnt3 catenin ... See more keywords
Yiqi Jianpi Huayu Jiedu Decoction Inhibits Metastasis of Colon Adenocarcinoma by Reversing Hsa-miR-374a-3p/Wnt3/β-Catenin-Mediated Epithelial–Mesenchymal Transition and Cellular Plasticity
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DOI: 10.3389/fonc.2022.904911
Abstract: Colon adenocarcinoma (COAD) accounts for 95% of colon cancer cases, with the 5-year survival rate significantly affected by local or distant metastases. Yiqi Jianpi Huayu Jiedu decoction (YJHJD), based on the theory of “nourish qi,… read more here.
Keywords: cellular plasticity; hsa mir; mir 374a; wnt3 catenin ... See more keywords
Neuroprotective Effects of Phytochemicals against Aluminum Chloride-Induced Alzheimer’s Disease through ApoE4/LRP1, Wnt3/β-Catenin/GSK3β, and TLR4/NLRP3 Pathways with Physical and Mental Activities in a Rat Model
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DOI: 10.3390/ph15081008
Abstract: Background: Alzheimer’s disease (AD) is a neurodegenerative disorder that is associated with abnormal cognition. AD is aided in its initiation and progression by hereditary and environmental factors. Aluminum (Al) is a neurotoxic agent that causes… read more here.
Keywords: tlr4; apoe4 lrp1; wnt3 catenin;