Wnt3a-Loaded Extracellular Vesicles Promote Alveolar Epithelial Regeneration after Lung Injury.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202206606
Abstract: Compromised regeneration resulting from the deactivation of Wnt/β-catenin signaling contributes to the progression of chronic obstructive pulmonary disease (COPD) with limited therapeutic options. Extracellular cytokine-induced Wnt-based signaling provides an alternative option for COPD treatment. However,… read more here.
Keywords: regeneration; extracellular vesicles; alveolar epithelial; injury ... See more keywords
WNT3A‐loaded exosomes enable cartilage repair
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12088
Abstract: Abstract Cartilage defects repair poorly. Recent genetic studies suggest that WNT3a may contribute to cartilage regeneration, however the dense, avascular cartilage extracellular matrix limits its penetration and signalling to chondrocytes. Extracellular vesicles actively penetrate intact… read more here.
Keywords: osteochondral defects; cartilage; loaded exosomes; wnt3a loaded ... See more keywords
LncRNA NONHSAT009968 inhibits the osteogenic differentiation of hBMMSCs in SA-induced inflammation via Wnt3a.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.08.086
Abstract: Osteomyelitis is one of the most challenging diseases in the field of orthopedics for its complex pathogenesis and unsatisfactory treatment. The mechanism underlying its occurrence and development is still unclear. In our previous study, we… read more here.
Keywords: osteogenic differentiation; differentiation; lncrna nonhsat009968; differentiation hbmmscs ... See more keywords
Targeting β-catenin dependent Wnt signaling via peptidomimetic inhibitors in murine chondrocytes and OA cartilage.
Sign Up to like & getrecommendations! Published in 2018 at "Osteoarthritis and cartilage"
DOI: 10.1016/j.joca.2018.02.908
Abstract: OBJECTIVE The canonical Wnt signaling pathway has been shown to be involved in regulating chondrocyte hypertrophic differentiation during Osteoarthritis (OA). The aim of this study was to test the therapeutic potential of two stapled peptide… read more here.
Keywords: murine chondrocytes; wnt signaling; wnt; chondrocytes cartilage ... See more keywords
RhoA GTPase phosphorylated at tyrosine 42 by src kinase binds to β-catenin and contributes transcriptional regulation of vimentin upon Wnt3A
Sign Up to like & getrecommendations! Published in 2020 at "Redox Biology"
DOI: 10.1016/j.redox.2020.101842
Abstract: In the Wnt canonical pathway, Wnt3A has been known to stabilize β-catenin. In the non-canonical Wnt signaling pathway, Wnt is known to activate Rho GTPases. The correlation between canonical and non-canonical pathways by Wnt signaling,… read more here.
Keywords: wnt3a; rhoa; kinase; catenin ... See more keywords
Wnt3a promotes odonto/osteogenic differentiation in vitro and tertiary dentin formation in a rat model.
Sign Up to like & getrecommendations! Published in 2023 at "International endodontic journal"
DOI: 10.1111/iej.13888
Abstract: AIM To investigate the effect of Wnt3a on odonto/osteogenic differentiation of stem cells isolated from human exfoliated deciduous teeth (SHEDs) and reparative dentine formation in a rat model. METHODOLOGY SHEDs were cultured in media with… read more here.
Keywords: dentine; odonto osteogenic; osteogenic differentiation; formation ... See more keywords
Exosomes Derived from Dermal Papilla Cells Mediate Hair Follicle Stem Cell Proliferation through the Wnt3a/β-Catenin Signaling Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/9042345
Abstract: Both hair follicle stem cells (HFSC) and dermal papilla cells (DPC) are essential for hair follicle growth and proliferation. In this study, HFSCs and DPCs that made signature proteins like KRT14, KRT15, KRT19, α-SMA, and… read more here.
Keywords: signaling pathway; proliferation; hair; catenin signaling ... See more keywords
Wnt3a/β-Catenin/CBP Activation in the Progression of Cervical Intraepithelial Neoplasia
Sign Up to like & getrecommendations! Published in 2021 at "Pathology and Oncology Research"
DOI: 10.3389/pore.2021.609620
Abstract: Piwil2 reprograms HPV-infected reserve cells in the cervix into tumor-initiated cells (TICs) and upregulates Wnt3a expression sequentially, which leads to cervical intraepithelial neoplasia (CIN) and ultimately squamous cell carcinoma (SCC). However, little is known regarding… read more here.
Keywords: wnt3a; intraepithelial neoplasia; progression cervical; expression ... See more keywords
Tumor Suppressor miRNA-503 Inhibits Cell Invasion in Head and Neck Cancer through the Wnt Signaling Pathway via the WNT3A/MMP Molecular Axis
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232415900
Abstract: Head and neck cancer (HNC) is the fifth most common cancer worldwide, and its incidence and death rates have been consistently high throughout the past decades. MicroRNAs (miRNAs) have recently gained significant attention because of… read more here.
Keywords: signaling pathway; head neck; mir 503; invasion ... See more keywords
hsa‑miR‑216a‑3p regulates cell proliferation in oral cancer via the Wnt3a/β‑catenin pathway
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2023.13015
Abstract: Oral cancer is one of the leading causes of death worldwide, with a reported 5-year survival rate of ~50% after treatment. The treatment measures for oral cancer are very expensive and affordability is low. Thus,… read more here.
Keywords: pathway; oral cancer; mir 216a; catenin ... See more keywords