Critical role of miR‐26a‐5p/Wnt5a signaling in gambogic acid‐induced inhibition of gastric cancer
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22721
Abstract: Gastric cancer (GC) represents the fifth most human malignant disease and the third‐most common cause of cancer‐related death. Gambogic acid (GA) is a natural compound with a polyprenylated xanthone structure and possesses remarkable antitumor activity… read more here.
Keywords: mir 26a; gambogic acid; gastric cancer; wnt5a ... See more keywords
Wnt5a is elevated in heart failure and affects cardiac fibroblast function
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Medicine"
DOI: 10.1007/s00109-017-1529-1
Abstract: Wnt signaling is dysregulated in heart failure (HF) and may promote cardiac hypertrophy, fibrosis, and inflammation. Blocking the Wnt ligand Wnt5a prevents HF in animal models. However, the role of Wnt5a in human HF and… read more here.
Keywords: wnt5a elevated; cardiac fibroblasts; heart failure; wnt5a ... See more keywords
Wnt5a plays a critical role in anal opening in mice at an early stage of embryonic development
Sign Up to like & getrecommendations! Published in 2022 at "Pediatric Surgery International"
DOI: 10.1007/s00383-022-05103-4
Abstract: Anorectal malformations are associated with other organ malformations. Proximodistal elongation of the cloacal plate and anal opening at its distal end are essential for anal development. However, the anal developmental stage in which Wnt5a is… read more here.
Keywords: development; anal opening; mice; wnt5a ... See more keywords
Wnt5a induces catabolic signaling and matrix metalloproteinase production in human articular chondrocytes.
Sign Up to like & getrecommendations! Published in 2017 at "Osteoarthritis and cartilage"
DOI: 10.1016/j.joca.2017.05.018
Abstract: OBJECTIVE Aberrant Wnt signaling may contribute to osteoarthritis (OA) but the Wnt family members involved have not been fully identified. The purpose of this study was to investigate the role of Wnt5a as a potential… read more here.
Keywords: production; kinase; normal human; wnt5a ... See more keywords
WNT5A-Ca2+-CaN-NFAT signalling plays a permissive role during cartilage differentiation in embryonic chick digit development.
Sign Up to like & getrecommendations! Published in 2020 at "Developmental biology"
DOI: 10.1016/j.ydbio.2020.10.003
Abstract: During digit development, the correct balance of chondrogenic signals ensures the recruitment of undifferentiated cells into the cartilage lineage or the maintenance of cells at the undifferentiated stage. WNT/β catenin maintains the pool of progenitor… read more here.
Keywords: cartilage differentiation; ca2; wnt5a; digit development ... See more keywords
Nucleoside reverse transcriptase inhibitors (NRTIs) induce proinflammatory cytokines in the CNS via Wnt5a signaling
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-03446-w
Abstract: HAART is very effective in suppressing HIV-1 replication in patients. However, patients staying on long-term HAART still develop various HIV-associated neurological disorders, even when the viral load is low. The underlying pathogenic mechanisms are largely… read more here.
Keywords: wnt5a; proinflammatory cytokines; nucleoside reverse; wnt5a signaling ... See more keywords
Wnt5a is associated with right ventricular dysfunction and adverse outcome in dilated cardiomyopathy
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-03625-9
Abstract: The Wingless (Wnt) pathway has been implicated in the pathogenesis of dilated cardiomyopathy (DCM). To explore the role of Wnt modulators Wnt5a and sFRP3 in DCM patients we analyzed the expression of Wnt5a and sFRP3… read more here.
Keywords: adverse outcome; dcm; right ventricular; wnt5a ... See more keywords
Wnt5a promotes epithelial-to-mesenchymal transition and metastasis in non-small-cell lung cancer
Sign Up to like & getrecommendations! Published in 2017 at "Bioscience Reports"
DOI: 10.1042/bsr20171092
Abstract: A recent study indicated that high Wnt5a expression is associated with poor prognosis in non-small-cell lung cancer (NSCLC) patients; however, the underlying mechanism was not clear yet. Immunohistochemistry and Western blotting were performed to examine… read more here.
Keywords: wnt5a; cell lung; metastasis; non small ... See more keywords
miR-637 Inhibits Osteogenic Differentiation of Human Intervertebral Disc Cartilage Endplate Stem Cells by Targeting WNT5A
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Investigative Surgery"
DOI: 10.1080/08941939.2022.2050857
Abstract: Abstract Background: Degenerative disk disease (DDD) remains the leading incentive of severe lumbago. DDD is mainly caused by degeneration of cartilage endplate (CEP). Cartilage endplate stem cells (CESCs) are essential in chondrogenesis and osteogenesis of… read more here.
Keywords: mir 637; differentiation cescs; osteogenic differentiation; wnt5a ... See more keywords
LncRNA CRNDE exacerbates neuropathic pain in chronic constriction injury-induced(CCI) rats through regulating miR-146a-5p/WNT5A pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Bioengineered"
DOI: 10.1080/21655979.2021.1972901
Abstract: Neuropathic pain (NP) originating from a dysfunction in the nervous system is often intractable and chronic. Many studies have implicated long noncoding RNAs (lncRNAs) in the physiological and pathological development of NP. The lncRNA colorectal… read more here.
Keywords: mir 146a; cci rats; neuropathic pain; wnt5a ... See more keywords
WNT5a Regulates Epithelial Morphogenesis in the Developing Choroid Plexus.
Sign Up to like & getrecommendations! Published in 2020 at "Cerebral cortex"
DOI: 10.1093/cercor/bhz330
Abstract: The choroid plexus (CP) is the predominant supplier of cerebral spinal fluid (CSF) and the site of the blood-CSF barrier and is thus essential for brain development and central nervous system homeostasis. Despite these crucial… read more here.
Keywords: wnt5a regulates; choroid plexus; epithelial morphogenesis; wnt5a ... See more keywords