Wnt7a, frequently silenced by CpG methylation, inhibits tumor growth and metastasis via suppressing epithelialâmesenchymal transition in gastric cancer
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29118
Abstract: Wnt7a is a member of the Wnt family and has been reported to be involved in the carcinogenesis and progression of many types of human cancer. However, little is known about Wnt7a expression and function… read more here.
Keywords: wnt7a; gastric cancer; metastasis; epithelial mesenchymal ... See more keywords
SU14 TRANSCRIPTOME ANALYSIS OF WNT7A-MEDIATED GENE EXPRESSION IN HUMAN NEURAL PROGENITOR CELLS DERIVED FROM CONTROL AND CHD8 HAPLOINSUFFICIENT INDUCED PLURIPOTENT STEM CELLS
Sign Up to like & getrecommendations! Published in 2019 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.08.203
Abstract: Background CHD8 (Chromodomain Helicase DNA Binding Protein 8) codes for a member of the CHD family of chromatin-remodeling factors and is one of the most commonly mutated genes in Autism Spectrum Disorders (ASD) identified in… read more here.
Keywords: wnt7a; control; gene expression; chd8 ... See more keywords
WNT7A/B promote choroidal neovascularization.
Sign Up to like & getrecommendations! Published in 2018 at "Experimental eye research"
DOI: 10.1016/j.exer.2018.05.033
Abstract: Perturbations in WNT signaling are associated with congenital eye disorders, including familial exudative vitreoretinopathy and Norrie disease. More recently, activation of the WNT pathway has also been shown to be associated with age-related macular degeneration… read more here.
Keywords: choroidal neovascularization; wnt7a; wnt7a wnt7b;
Long-noncoding RNA HOXA transcript at the distal tip ameliorates the insulin resistance and hepatic gluconeogenesis in mice with gestational diabetes mellitus via the microRNA-423-5p/wingless-type MMTV integration site family member 7A axis
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2076982
Abstract: ABSTRACT Long-noncoding RNA HOXA transcript at the distal tip (HOTTIP) has been probed to exert essential effects on diabetes progression, while its function in gestational diabetes mellitus (GDM) remains unclear. This study was committed to… read more here.
Keywords: mir 423; gdm mice; wnt7a; hottip ... See more keywords
Overexpression of Wnt7a enhances radiosensitivity of non-small-cell lung cancer via the Wnt/JNK pathway
Sign Up to like & getrecommendations! Published in 2020 at "Biology Open"
DOI: 10.1242/bio.050575
Abstract: ABSTRACT The Wingless-type protein 7a (Wnt7a) plays an antiproliferative role in non-small-cell lung cancer (NSCLC). Previous studies have indicated that Wnt7a expression was downregulated in radiation-resistant NSCLC cells. However, little is known about its biological… read more here.
Keywords: overexpression; wnt7a; cell; jnk ... See more keywords
Exogenous Expression of WNT7A in Leukemia-Derived Cell Lines Induces Resistance to Chemotherapeutic Agents.
Sign Up to like & getrecommendations! Published in 2020 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/1871520620666200521114100
Abstract: BACKGROUND Dysregulations of the WNT pathway are implicated in the malignant transformation of different types of neoplasia's. WNT7A is expressed in normal peripheral lymphocytes but in the tumoral counterpart is decreased. Furthermore, treatment of leukemic… read more here.
Keywords: wnt7a; chemotherapeutic agents; cell lines; proliferation ... See more keywords