Pkd1-targeted mutation reveals a role for the Wolffian duct in autosomal dominant polycystic kidney disease
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Developmental Origins of Health and Disease"
DOI: 10.1017/s2040174419000436
Abstract: Abstract Several life-threatening diseases of the kidney have their origins in mutational events that occur during embryonic development. In this study, we investigate the role of the Wolffian duct (WD), the earliest embryonic epithelial progenitor… read more here.
Keywords: autosomal dominant; wolffian duct; pkd1; disease ... See more keywords
Hedgehog signaling regulates Wolffian duct development through the primary cilium
Sign Up to like & getrecommendations! Published in 2022 at "Biology of Reproduction"
DOI: 10.1093/biolre/ioac210
Abstract: Abstract Primary cilia play pivotal roles in embryonic patterning and organogenesis through transduction of the Hedgehog signaling pathway (Hh). Although mutations in Hh morphogens impair the development of the gonads and trigger male infertility, the… read more here.
Keywords: development; wolffian duct; primary cilia; hedgehog signaling ... See more keywords