Positive cardiac inotrope omecamtiv mecarbil activates muscle despite suppressing the myosin working stroke
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-06193-2
Abstract: Omecamtiv mecarbil (OM) is a positive cardiac inotrope in phase-3 clinical trials for treatment of heart failure. Although initially described as a direct myosin activator, subsequent studies are at odds with this description and do… read more here.
Keywords: omecamtiv mecarbil; myosin; cardiac inotrope; working stroke ... See more keywords
Myosin with hypertrophic cardiac mutation R712L has a decreased working stroke which is rescued by omecamtiv mecarbil
Sign Up to like & getrecommendations! Published in 2021 at "eLife"
DOI: 10.7554/elife.63691
Abstract: Hypertrophic cardiomyopathies (HCMs) are the leading cause of acute cardiac failure in young individuals. Over 300 mutations throughout β-cardiac myosin, including in the motor domain, are associated with HCM. A β-cardiac myosin motor mutation (R712L)… read more here.
Keywords: myosin; mutation r712l; working stroke;