Comparing Cardiovascular Outcomes With Degarelix or Leuprolide as Prostate Cancer Therapy-Applying Real-world Data to Clinical Trial Emulation.
Sign Up to like & getrecommendations! Published in 2021 at "JAMA network open"
DOI: 10.1001/jamanetworkopen.2021.31429
Abstract: Since the early 1980s, androgen deprivation therapy (ADT) with gonadotropin-releasing hormone (GnRH) agonist or antagonist therapies has remained the primary systemic therapy for men with prostate cancer, owing to the fundamental reliance of the disease… read more here.
Keywords: real world; trial; comparing cardiovascular; prostate cancer ... See more keywords
A real-world data analysis of predictors of early mortality after a diagnosis of multiple myeloma.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer"
DOI: 10.1002/cncr.34760
Abstract: Despite the increased availability and use of novel therapies for multiple myeloma, early mortality is a pervasive challenge with a significant impact on older adults. Reported rates and predictors of early mortality have varied in… read more here.
Keywords: world data; mortality; early mortality; predictors early ... See more keywords
From Discovery to Practice and Survivorship: Building a National Real‐World Data Learning Healthcare Framework for Military and Veteran Cancer Patients
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.1425
Abstract: The Applied Proteogenomics OrganizationaL Learning and Outcomes (APOLLO) network is implementing a prospective curation and translation of real-world data into real-world evidence within the learning healthcare environment of the Department of Defense and Department of… read more here.
Keywords: real world; learning healthcare; practice; world ... See more keywords
Real‐World Data: An Unrealized Opportunity in Global Health?
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.1476
Abstract: < http://nationalacademies.org/hmd/ Reports/2018/returning-individualresearch-results-to-participants.aspx > ( 2018 ). Accessed February 12, 2019. 11 . APOLLO-1-VA pilot lung cancer study data in The Cancer Imaging Archive (TCIA) < https://wiki.cancerimagingarchive.net/ display/Public/APOLLO-1-VA > ( 2018 ). Accessed February 12,… read more here.
Keywords: real world; february 2019; 2018 accessed; accessed february ... See more keywords
Drugs in COVID‐19 Clinical Trials: Predicting Transporter‐Mediated Drug‐Drug Interactions Using In Vitro Assays and Real‐World Data
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.2236
Abstract: Numerous drugs are currently under accelerated clinical investigation for the treatment of coronavirus disease 2019 (COVID‐19); however, well‐established safety and efficacy data for these drugs are limited. The goal of this study was to predict… read more here.
Keywords: real world; drug interactions; drug; clinical trials ... See more keywords
Real-World Data of Palbociclib in Combination With Endocrine Therapy for the Treatment of Metastatic Breast Cancer in Men.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical pharmacology and therapeutics"
DOI: 10.1002/cpt.2454
Abstract: This report examined the benefits and risks of palbociclib plus endocrine therapy (ET) in men with hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-) metastatic breast cancer (MBC). Palbociclib was evaluated using 3 independent… read more here.
Keywords: real world; treatment; palbociclib plus; world ... See more keywords
The Use of Real-world Data to Assess the Impact of Safety-related Regulatory Interventions.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical pharmacology and therapeutics"
DOI: 10.1002/cpt.2464
Abstract: The regulation of medicines seeks to ensure the efficacy, safety and quality of prescription and non-prescription medicines. Given that the conditions under which a medicine's benefits outweigh its risks are complex, it is essential that… read more here.
Keywords: real world; impact; safety; use real ... See more keywords
Incidence and impact of atrial fibrillation in heart failure patients: real‐world data in a large community
Sign Up to like & getrecommendations! Published in 2022 at "ESC Heart Failure"
DOI: 10.1002/ehf2.14124
Abstract: The objective of the present study is to assess the bidirectional association between heart failure (HF) and atrial fibrillation (AF) using real‐world data. read more here.
Keywords: heart failure; world data; heart; atrial fibrillation ... See more keywords
Real‐world data on cannabidiol treatment of various epilepsy subtypes: A retrospective, multicenter study
Sign Up to like & getrecommendations! Published in 2023 at "Epilepsia Open"
DOI: 10.1002/epi4.12699
Abstract: Cannabidiol (CBD) is approved for treatment of Dravet syndrome (DS), Lennox‐Gastaut syndrome (LGS), and tuberous sclerosis complex (TSC). Several studies suggest antiseizure effects also beyond these three epilepsy syndromes. read more here.
Keywords: world data; cannabidiol treatment; epilepsy; treatment ... See more keywords
Natural History and Real‐World Data in Rare Diseases: Applications, Limitations, and Future Perspectives
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Pharmacology"
DOI: 10.1002/jcph.2134
Abstract: Rare diseases represent a highly heterogeneous group of disorders with high phenotypic and genotypic diversity within individual conditions. Due to the small numbers of people affected, there are unique challenges in understanding rare diseases and… read more here.
Keywords: natural history; world data; rare diseases; real world ... See more keywords
Considerations when evaluating real‐world data quality in the context of fitness for purpose
Sign Up to like & getrecommendations! Published in 2020 at "Pharmacoepidemiology and Drug Safety"
DOI: 10.1002/pds.5010
Abstract: With the growing use of large real-world clinical datasets comes increased scrutiny about the quality of real-world data (RWD). The question of whether the data are good enough for decision-making is often raised. It is… read more here.
Keywords: quality; research; real world; fitness purpose ... See more keywords