Real‐world evidence following a mandatory treatment break after a 1‐year prophylactic treatment with calcitonin gene‐related peptide (pathway) monoclonal antibodies
Sign Up to like & getrecommendations! Published in 2022 at "Brain and Behavior"
DOI: 10.1002/brb3.2662
Abstract: Current German and European guidelines suggest migraine patients undertake a treatment break after 9 to 12 months of treatment with CGRP (pathway) monoclonal antibodies. read more here.
Keywords: pathway monoclonal; world evidence; treatment break; treatment ... See more keywords
Artificial intelligence to unlock real‐world evidence in clinical oncology: A primer on recent advances
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Medicine"
DOI: 10.1002/cam4.7253
Abstract: Real world evidence is crucial to understanding the diffusion of new oncologic therapies, monitoring cancer outcomes, and detecting unexpected toxicities. In practice, real world evidence is challenging to collect rapidly and comprehensively, often requiring expensive… read more here.
Keywords: oncology; real world; artificial intelligence; world evidence ... See more keywords
Randomized Controlled Trials Versus Real World Evidence: Neither Magic Nor Myth
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.2083
Abstract: Compared with drugs from the blockbuster era, recently authorized drugs and those expected in the future present a heterogenous mix of chemicals, biologicals, and cell and gene therapies, a sizable fraction being for rare diseases,… read more here.
Keywords: real world; world evidence; randomized controlled; evidence ... See more keywords
When Can We Rely on Real‐World Evidence to Evaluate New Medical Treatments?
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.2253
Abstract: Concerns regarding both the limited generalizability and the slow pace of traditional randomized trials have led to calls for greater use of real‐world evidence (RWE) in the evaluation of new treatments or products. The RWE… read more here.
Keywords: real world; world evidence; evaluate new; medical treatments ... See more keywords
Integrated Evidence Planning for Enhancing Patient Care: Harnessing the Power of Real‐World Evidence
Sign Up to like & getrecommendations! Published in 2025 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.3632
Abstract: Real‐World Evidence (RWE), as an important pillar of Integrated Evidence Plans (IEP), offers a promising tool to address numerous hurdles impeding patients to receive timely and adequate treatments. read more here.
Keywords: evidence planning; real world; integrated evidence; world evidence ... See more keywords
The real‐world evidence of heart failure co‐morbidities
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Heart Failure"
DOI: 10.1002/ejhf.751
Abstract: We would like to thank Maggioni et al. for their recent publication investigating the comorbidities/patient characteristics in heart failure (HF) that are found in the real world, as opposed to those garnered from clinical trials.1… read more here.
Keywords: real world; world evidence; heart; heart failure ... See more keywords
The utility of real‐world evidence for benefit‐risk assessment, communication, and evaluation of pharmaceuticals: Case studies
Sign Up to like & getrecommendations! Published in 2020 at "Pharmacoepidemiology and Drug Safety"
DOI: 10.1002/pds.5167
Abstract: In recent years, novel types of real‐world evidence (RWE) have played a role in various decision‐making processes relating to medicinal products, including regulatory approval, patient access, health technology assessment, safety monitoring, clinical use, and post‐approval… read more here.
Keywords: real world; world evidence; risk; risk assessment ... See more keywords
HARmonized Protocol Template to Enhance Reproducibility of hypothesis evaluating real‐world evidence studies on treatment effects: A good practices report of a joint ISPE/ISPOR task force
Sign Up to like & getrecommendations! Published in 2022 at "Pharmacoepidemiology and Drug Safety"
DOI: 10.1002/pds.5507
Abstract: Ambiguity in communication of key study parameters limits the utility of real‐world evidence (RWE) studies in healthcare decision‐making. Clear communication about data provenance, design, analysis, and implementation is needed. This would facilitate reproducibility, replication in… read more here.
Keywords: harmonized protocol; reproducibility; real world; world evidence ... See more keywords
Real‐World Evidence BRIDGE: A Tool to Connect Protocol With Code Programming
Sign Up to like & getrecommendations! Published in 2024 at "Pharmacoepidemiology and Drug Safety"
DOI: 10.1002/pds.70062
Abstract: To enhance documentation on programming decisions in Real World Evidence (RWE) studies. read more here.
Keywords: evidence bridge; bridge tool; real world; world evidence ... See more keywords
Real-world evidence: the devil is in the detail
Sign Up to like & getrecommendations! Published in 2020 at "Diabetologia"
DOI: 10.1007/s00125-020-05217-1
Abstract: Much has been written about real-world evidence (RWE), a concept that offers an understanding of the effects of healthcare interventions using routine clinical data. The reflection of diverse real-world practices is a double-edged sword that… read more here.
Keywords: real world; world evidence; evidence devil; world ... See more keywords
The medical treatment with pasireotide in Cushing’s disease: an Italian multicentre experience based on “real-world evidence”
Sign Up to like & getrecommendations! Published in 2018 at "Endocrine"
DOI: 10.1007/s12020-018-1818-7
Abstract: A phase III study has demonstrated that 6-month pasireotide treatment induced disease control with good safety in 15–26% of patients with Cushing’s disease (CD). The aim of the current study was to evaluate the 6-month… read more here.
Keywords: cushing disease; real world; world evidence; treatment ... See more keywords