Anticoagulants for Cardioembolism Prevention in Atrial Fibrillation Patients: Potential Bias From Real-World Studies.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2018.07.104
Abstract: The study conducted by Kirchhof et al. [(1)][1] showed low bleeding and stroke rates in rivaroxaban-treated patients with atrial fibrillation (AF). We would emphasize the potential bias of including more low-risk patients in real-world studies, because… read more here.
Keywords: atrial fibrillation; real world; world studies; potential bias ... See more keywords
Real-world studies no substitute for RCTs in establishing efficacy
Sign Up to like & getrecommendations! Published in 2019 at "The Lancet"
DOI: 10.1016/s0140-6736(18)32840-x
Abstract: 210 www.thelancet.com Vol 393 January 19, 2019 We live in the real world, so it is reasonable to expect that data collected from the real world should help identify effective therapies. Indeed, rapid increases in… read more here.
Keywords: world; world studies; insulin; establishing efficacy ... See more keywords
Coming to know Indigeneity: Epistemologies of ignorance in the 2003–2015 Ontario Canadian and World Studies Curriculum
Sign Up to like & getrecommendations! Published in 2018 at "Curriculum Inquiry"
DOI: 10.1080/03626784.2018.1518113
Abstract: Abstract This article investigates the portrayal of colonialism and Indigenous peoples in curricula and textbooks in the province of Ontario, Canada. The analysis is focused on the curricular documents and texts that constituted Ontario’s social… read more here.
Keywords: 2003 2015; canadian world; world studies; epistemologies ignorance ... See more keywords
An overview of methodological flaws of real-world studies investigating drug safety in the post-marketing setting.
Sign Up to like & getrecommendations! Published in 2023 at "Expert opinion on drug safety"
DOI: 10.1080/14740338.2023.2219892
Abstract: INTRODUCTION The evaluation of the post-marketing safety profile of drugs is a continuous monitoring process for approved and marketed medicines and it is crucial for detecting new adverse drug reactions. As such, real-world studies are… read more here.
Keywords: safety; world; marketing; world studies ... See more keywords
How effective are JAK-inhibitors? Perspectives from clinical trials and real-world studies
Sign Up to like & getrecommendations! Published in 2021 at "Expert Review of Clinical Immunology"
DOI: 10.1080/1744666x.2021.1982383
Abstract: ABSTRACT Introduction JAK-inhibitors have emerged as a new treatment option for rheumatoid arthritis, with five molecules currently available in different parts of the world: tofacitinib, baricitinib, upadacitinib, peficitinib, and filgotinib. These molecules have been the… read more here.
Keywords: trials real; world; world studies; real world ... See more keywords
Worldwide Trends in Registering Real-World Studies at ClinicalTrials.gov: A Cross-Sectional Analysis
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of General Medicine"
DOI: 10.2147/ijgm.s402478
Abstract: Objective The purpose of this study was to characterize real-world studies (RWSs) registered at ClinicalTrials.gov to help investigators better conduct relevant research in clinical practice. Methods A retrospective analysis of 944 studies was performed on… read more here.
Keywords: world studies; analysis; real world; clinicaltrials gov ... See more keywords
Real-world studies: bridging the gap between trial-assessed efficacy and routine care
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biomedical Research"
DOI: 10.7555/jbr.36.20220040
Abstract: Even though randomized controlled clinical trials (RCTs) have been accepted as the gold standard for official assessment of novel interventions, there is a substantial gap between the efficacy observed in RCTs and the impact on… read more here.
Keywords: world studies; efficacy; gap; studies bridging ... See more keywords