Coordination of Functional Oligonucleotides Yields a Versatile Nanocomposite Microneedle Patch to Facilitate Local Wound Microenvironment Remodeling via Systemic Hyperglycemia Regulation
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202423012
Abstract: Hyperglycemia exacerbates bacterial infections, disrupts angiogenesis, and perpetuates chronic inflammation in the wound. Therefore, the effective management of diabetic wounds necessitates a synergistic approach that integrates local wound microenvironment remodeling with systemic hyperglycemia regulation. Herein,… read more here.
Keywords: wound microenvironment; local wound; wound; hyperglycemia ... See more keywords
Oxidative Stimuli-responsive "pollen-like" Exosomes from Silver Nanoflowers Remodeling Diabetic Wound Microenvironment for Accelerating wound Healing.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202300456
Abstract: The hostile oxidative wound microenvironment, defective angiogenesis and uncontrolled release of therapeutic factors are major challenges in improving the diabetic wound healing. Herein, adipose-derived stem cell (ADSC)-derived exosomes (Exos) were firstly loaded into Ag@bovine serum… read more here.
Keywords: wound; microenvironment; wound healing; wound microenvironment ... See more keywords
Oxygen-Vacancy-Engineered Self-Regenerative Nanozymes in Dual-Signal-Responsive Dynamic Hydrogels: A Closed-Loop Therapeutic Strategy for Diabetic Wound Microenvironment Remodeling.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202504199
Abstract: Diabetic wounds are trapped in a self-perpetuating pathological triad of hypoxia, infection, and oxidative stressdisrupting physiological wound healing and causing recalcitrant nonhealing ulcerswhile conventional therapies, limited by static interventions and simplistic co-delivery, fail to adapt… read more here.
Keywords: wound microenvironment; oxygen vacancy; wound; closed loop ... See more keywords
Intelligent Carbon Dots with Switchable Photo‐Activated Oxidase‐Mimicking Activity and pH Responsive Antioxidant Activity Adaptive to the Wound Microenvironment for Selective Antibacterial Therapy
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DOI: 10.1002/advs.202406681
Abstract: Intelligent antibacterial agent with controllable activities adaptive to the wound microenvironment is appealing to reduce drug resistance and enhance antibacterial efficiency. In this study, celery is chosen as the carbon source to construct celery‐based carbon… read more here.
Keywords: carbon dots; wound microenvironment; mimicking activity; adaptive wound ... See more keywords
Wound Microenvironment-Responsive Protein Hydrogel Drug-Loaded System with Accelerating Healing and Antibacterial Property.
Sign Up to like & getrecommendations! Published in 2022 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c00373
Abstract: Growth factors play a vital role in wound healing, and novel hydrogel carriers suitable for growth factors have always been a research hotspot in the wound healthcare field. In this work, a wound microenvironment-responsive hydrogel… read more here.
Keywords: system; microenvironment responsive; growth; wound microenvironment ... See more keywords
Lactobacillus rhamnosus GG and Bifidobacterium animalis subsp. lactis BB‐12 promote infected wound healing via regulation of the wound microenvironment
Sign Up to like & getrecommendations! Published in 2024 at "Microbial Biotechnology"
DOI: 10.1111/1751-7915.70031
Abstract: Infected wounds can result in complex clinical complications and delayed healing, presenting a significant global public health challenge. This study explored the effects of topical application of two probiotics, Lactobacillus rhamnosus GG (LGG) and Bifidobacterium… read more here.
Keywords: subsp lactis; bifidobacterium animalis; wound microenvironment; wound healing ... See more keywords
Wound-Microenvironment Engineering through Advanced-Dressing Bioprinting
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23052836
Abstract: In patients with comorbidities, a large number of wounds become chronic, representing an overwhelming economic burden for healthcare systems. Engineering the microenvironment is a paramount trend to activate cells and burst-healing mechanisms. The extrusion bioprinting… read more here.
Keywords: microenvironment; microenvironment engineering; wound microenvironment; advanced dressing ... See more keywords