Activation of Engineered Protein Tyrosine Phosphatases with the Biarsenical Compound AsCy3‐EDT2
Sign Up to like & getrecommendations! Published in 2017 at "ChemBioChem"
DOI: 10.1002/cbic.201700253
Abstract: Methods for activating signaling enzymes hold significant potential for the study of cellular signal transduction. Here we present a strategy for engineering chemically activatable protein tyrosine phosphatases (actPTPs). To generate actPTP1B, we introduced three cysteine… read more here.
Keywords: tyrosine phosphatases; ascy3 edt2; wpd loop; protein tyrosine ... See more keywords
A structural exposé of noncanonical molecular reactivity within the protein tyrosine phosphatase WPD loop.
Sign Up to like & getrecommendations! Published in 2022 at "Nature communications"
DOI: 10.1038/s41467-022-29673-y
Abstract: Structural snapshots of protein/ligand complexes are a prerequisite for gaining atomic level insight into enzymatic reaction mechanisms. An important group of enzymes has been deprived of this analytical privilege: members of the protein tyrosine phosphatase… read more here.
Keywords: tyrosine phosphatase; structural expos; wpd loop; protein tyrosine ... See more keywords
Allosteric inhibition induces an open WPD-loop: a new avenue towards glioblastoma therapy
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DOI: 10.1039/c8ra08427k
Abstract: The mobility of loops around the catalytic site of a protein remains crucial to its activity. Dynamics of the WPD-loop is an essential determinant of the catalytic activity of tyrosine-protein phosphatase zeta, an implicated protein… read more here.
Keywords: protein; phosphatase zeta; wpd loop; tyrosine protein ... See more keywords