Low levels of WRAP53 predict decreased efficacy of radiotherapy and are prognostic for local recurrence and death from breast cancer: a long-term follow-up of the SweBCG91RT randomized trial.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular oncology"
DOI: 10.1002/1878-0261.13426
Abstract: Downregulation of the DNA repair protein WD40-encoding RNA antisense to p53 (WRAP53) has been associated with radiotherapy resistance and reduced cancer survival. The aim of this study was to evaluate WRAP53 protein and RNA levels… read more here.
Keywords: breast; wrap53; local recurrence; breast cancer ... See more keywords
Phosphorylation of the Cajal body protein WRAP53β by ATM promotes its involvement in the DNA damage response
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DOI: 10.1080/15476286.2016.1243647
Abstract: ABSTRACT The cellular response to DNA double-strand breaks is orchestrated by the protein kinase ATM, which phosphorylates key actors in the DNA repair network. WRAP53β is a multifunctional protein that controls trafficking of factors to… read more here.
Keywords: dna damage; response; damage; wrap53 ... See more keywords
Nuclear WRAP53 promotes neuronal survival and functional recovery after stroke
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DOI: 10.1126/sciadv.abc5702
Abstract: Ischemia-induced WRAP53 nuclear accumulation promotes DNA damage repair resulting in functional recovery after stroke. Failure of neurons to efficiently repair DNA double-strand breaks (DSBs) contributes to cerebral damage after stroke. However, the molecular machinery that… read more here.
Keywords: dna repair; functional recovery; recovery stroke; neuronal survival ... See more keywords
Clinical, cellular, and bioinformatic analyses reveal involvement of WRAP53 overexpression in carcinogenesis of lung adenocarcinoma
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DOI: 10.1177/1010428317694309
Abstract: Lung cancer, of which non-small cell lung cancer accounts for 80%, remains a leading cause of cancer-related mortality and morbidity worldwide. Our study revealed that the expression of WD repeat containing antisense to P53 (WRAP53)… read more here.
Keywords: lung adenocarcinoma; wrap53 overexpression; wrap53; lung ... See more keywords
The Role of WRAP53 in Cell Homeostasis and Carcinogenesis Onset
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DOI: 10.3390/cimb44110372
Abstract: The WD repeat containing antisense to TP53 (WRAP53) gene codifies an antisense transcript for tumor protein p53 (TP53), stabilization (WRAP53α), and a functional protein (WRAP53β, WDR79, or TCAB1). The WRAP53β protein functions as a scaffolding… read more here.
Keywords: wrap53; protein; cell homeostasis; role wrap53 ... See more keywords
Promoter methylation of Wrap53α, an antisense transcript of p53, is associated with the poor prognosis of patients with non-small cell lung cancer
Sign Up to like & getrecommendations! Published in 2018 at "Oncology Letters"
DOI: 10.3892/ol.2018.9404
Abstract: Lung cancer, of which non-small cell lung cancer (NSCLC) accounts for ~85% of cases, remains a leading cause of cancer-associated mortality and morbidity worldwide. Tumor suppressor p53 is a master regulator of diverse cellular processes… read more here.
Keywords: methylation; lung cancer; cancer; p53 ... See more keywords