Articles with "wrc" as a keyword



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Distinct Interaction Sites of Rac GTPase with WAVE Regulatory Complex Have Non-redundant Functions in Vivo

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Published in 2018 at "Current Biology"

DOI: 10.1016/j.cub.2018.10.002

Abstract: Summary Cell migration often involves the formation of sheet-like lamellipodia generated by branched actin filaments. The branches are initiated when Arp2/3 complex [1] is activated by WAVE regulatory complex (WRC) downstream of small GTPases of… read more here.

Keywords: wave regulatory; regulatory complex; site; wrc ... See more keywords
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In Silico Optimized Stapled Peptides Targeting WASF3 in Breast Cancer.

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Published in 2022 at "ACS medicinal chemistry letters"

DOI: 10.1021/acsmedchemlett.1c00627

Abstract: Wiskott-Aldrich Syndrome Protein Family (WASF) members regulate actin cytoskeletal dynamics, and WASF3 is directly associated with breast cancer metastasis and invasion. WASF3 forms a heteropentameric complex with CYFIP, NCKAP, ABI, and BRK1, called the WASF… read more here.

Keywords: cancer; wrc; breast cancer; cancer metastasis ... See more keywords
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FAT10 Induces cancer cell migration by stabilizing phosphorylated ABI3/NESH

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Published in 2023 at "Animal Cells and Systems"

DOI: 10.1080/19768354.2023.2186486

Abstract: ABSTRACT The WAVE regulatory complex (WRC) is involved in various cellular processes by regulating actin polymerization. The dysregulation of WRC components is associated with cancer development. ABI family member 3 (ABI3)/new molecule including SH3 (NESH)… read more here.

Keywords: abi3; phosphorylated form; wrc; cancer cell ... See more keywords
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Experimental and numerical study on the thrust of a water-retaining curtain

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Published in 2018 at "Journal of Hydroinformatics"

DOI: 10.2166/hydro.2017.095

Abstract: A water-retaining curtain (WRC) has become a useful facility in selective withdrawal and sedimentation control, but the force analysis of a curved curtain is still lacking. Based on flume experimental tests and numerical simulations, this… read more here.

Keywords: water; retaining curtain; wrc; water retaining ... See more keywords