Nicotine promotes WRL68 cells proliferation due to the mutant p53 gain-of-function by activating CDK6-p53-RS-PIN1-STAT1 signaling pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.0c00119
Abstract: The liver is an important organ with many tasks, such as dealing with drugs, alcohol and other toxins to remove them from the body. Nicotine is the more abundant component in cigarette smoking, which is… read more here.
Keywords: wrl68 cells; stat1; cells proliferation; mutant p53 ... See more keywords
Synchrotron Radiation FTIR Microspectroscopy Study of Biomolecular Alterations in Vincristine-Treated WRL68 Cells at the Single-Cell Level
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DOI: 10.1021/acsomega.2c06622
Abstract: The toxic effect of vincristine on hepatocytes has rarely been studied. Synchrotron radiation-based Fourier transform infrared (SR-FTIR) microspectroscopy is a novel technique for investigating drug–cell interaction systems. In this research, the biomolecular alterations in WRL68… read more here.
Keywords: ftir microspectroscopy; wrl68 cells; biomolecular alterations; vincristine treated ... See more keywords