WRN suppresses p53/PUMA-induced apoptosis in colorectal cancer with microsatellite instability/mismatch repair deficiency
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2219963120
Abstract: Colorectal cancer (CRC) initiates in the large intestine (colon or rectum) and is a leading cause of cancer-related deaths in the United States in both males and females and across all racial and ethnic groups… read more here.
Keywords: dna; wrn; mmr deficient; crc ... See more keywords
LncRNA KCNQ1OT1 promotes apoptosis and oxidative stress of human lens epithelial cells through epigenetic regulation of WRN.
Sign Up to like & getrecommendations! Published in 2022 at "Current eye research"
DOI: 10.1080/02713683.2022.2026975
Abstract: PURPOSE Long non-coding RNA KCNQ1OT1 is fundamental to age-related cataract (ARC), whereas the underlying mechanism is still unknown. Here, we explored the possible mechanism of KCNQ1OT1 in ARC. METHODS The expression of KCNQ1OT1 in ARC… read more here.
Keywords: wrn; apoptosis oxidative; sra01 cells; oxidative stress ... See more keywords
P2254Impaired autophagic off-rate causes cardiac aging in progeria mouse model
Sign Up to like & getrecommendations! Published in 2019 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehz748.0732
Abstract: Aging is known to be one of the primary causes of heart failure. Werner syndrome is one of the aging disorder that caused by dysfunction of DNA helicase-regulatory protein (WRN). However, there is little information… read more here.
Keywords: wrn; heart; cardiac aging; wrn k577m ... See more keywords
CDK2 phosphorylation of Werner protein (WRN) contributes to WRN's DNA double-strand break repair pathway choice.
Sign Up to like & getrecommendations! Published in 2021 at "Aging cell"
DOI: 10.1111/acel.13484
Abstract: Werner syndrome (WS) is an accelerated aging disorder characterized by genomic instability, which is caused by WRN protein deficiency. WRN participates in DNA metabolism including DNA repair. In a previous report, we showed that WRN… read more here.
Keywords: wrn; protein; pathway choice; phosphorylation ... See more keywords
Microsatellite Instability Causes Repeat Expansion and WRN Dependence.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-rw2020-149
Abstract: Cells with MSI accumulate unstable, structure-forming (TA)n repeats resolvable by the helicase WRN. read more here.
Keywords: causes repeat; wrn; instability causes; microsatellite instability ... See more keywords
WRN-Mutated Colorectal Cancer Is Characterized by a Distinct Genetic Phenotype
Sign Up to like & getrecommendations! Published in 2020 at "Cancers"
DOI: 10.3390/cancers12051319
Abstract: Werner syndrome gene (WRN) contributes to DNA repair. In cancer, WRN mutations (WRN-mut) lead to genomic instability. Thus, WRN is a promising target in cancers with microsatellite instability (MSI). We assessed this study to investigate… read more here.
Keywords: wrn; colorectal cancer; wrn mut; msi ... See more keywords