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   Articles with "wrn" as a keyword



WRN suppresses p53/PUMA-induced apoptosis in colorectal cancer with microsatellite instability/mismatch repair deficiency

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recommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2219963120

Abstract: Colorectal cancer (CRC) initiates in the large intestine (colon or rectum) and is a leading cause of cancer-related deaths in the United States in both males and females and across all racial and ethnic groups… read more here.

Keywords: dna; wrn; mmr deficient; crc ... See more keywords

LncRNA KCNQ1OT1 promotes apoptosis and oxidative stress of human lens epithelial cells through epigenetic regulation of WRN.

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recommendations! Published in 2022 at "Current eye research"

DOI: 10.1080/02713683.2022.2026975

Abstract: PURPOSE Long non-coding RNA KCNQ1OT1 is fundamental to age-related cataract (ARC), whereas the underlying mechanism is still unknown. Here, we explored the possible mechanism of KCNQ1OT1 in ARC. METHODS The expression of KCNQ1OT1 in ARC… read more here.

Keywords: wrn; apoptosis oxidative; sra01 cells; oxidative stress ... See more keywords

P2254Impaired autophagic off-rate causes cardiac aging in progeria mouse model

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recommendations! Published in 2019 at "European Heart Journal"

DOI: 10.1093/eurheartj/ehz748.0732

Abstract: Aging is known to be one of the primary causes of heart failure. Werner syndrome is one of the aging disorder that caused by dysfunction of DNA helicase-regulatory protein (WRN). However, there is little information… read more here.

Keywords: wrn; heart; cardiac aging; wrn k577m ... See more keywords
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CDK2 phosphorylation of Werner protein (WRN) contributes to WRN's DNA double-strand break repair pathway choice.

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recommendations! Published in 2021 at "Aging cell"

DOI: 10.1111/acel.13484

Abstract: Werner syndrome (WS) is an accelerated aging disorder characterized by genomic instability, which is caused by WRN protein deficiency. WRN participates in DNA metabolism including DNA repair. In a previous report, we showed that WRN… read more here.

Keywords: wrn; protein; pathway choice; phosphorylation ... See more keywords

Abstract 5921: PH027-1, a potent and selective small-molecule WRN inhibitor that targets MSI-H tumors

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recommendations! Published in 2024 at "Cancer Research"

DOI: 10.1158/1538-7445.am2024-5921

Abstract: Background: High microsatellite instability (MSI-H) is highly prevalent across many cancer types including endometrium, gastric, ovary and colorectal cancer. It is well known that there is a clear synthetic lethality (SL) interaction between MSI-H and… read more here.

Keywords: cancer; msi; inhibitor; wrn ... See more keywords

Abstract 4205: Direct measurement of TA repeat expansions significantly outperforms MSI-H status as a predictor of sensitivity to the novel WRN inhibitor MOMA-341

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recommendations! Published in 2025 at "Cancer Research"

DOI: 10.1158/1538-7445.am2025-4205

Abstract: MOMA-341, first disclosed herein, is a novel, potent, and selective clinical stage small molecule inhibitor of the Werner RecQ like helicase (WRN) that acts through an allosteric, ATP-competitive binding mechanism and covalent ligation of WRN… read more here.

Keywords: repeat; moma 341; wrn; sensitivity ... See more keywords

WRN Helicase: Is There More to MSI-H than Immunotherapy?

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recommendations! Published in 2024 at "Cancer discovery"

DOI: 10.1158/2159-8290.cd-24-0771

Abstract: In this issue, Picco and colleagues provide further evidence that WRN inhibitors are synthetically lethal in microsatellite instability-high (MSI-H) cancers and function by blocking the helicase domain of select WRN residues. They demonstrate that WRN… read more here.

Keywords: msi immunotherapy; msi; helicase msi; wrn ... See more keywords

Microsatellite Instability Causes Repeat Expansion and WRN Dependence.

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recommendations! Published in 2020 at "Cancer discovery"

DOI: 10.1158/2159-8290.cd-rw2020-149

Abstract: Cells with MSI accumulate unstable, structure-forming (TA)n repeats resolvable by the helicase WRN. read more here.

Keywords: causes repeat; wrn; instability causes; microsatellite instability ... See more keywords

Genetic and epigenetic insights into Werner Syndrome.

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recommendations! Published in 2025 at "Cytogenetic and genome research"

DOI: 10.1159/000544118

Abstract: BACKGROUND Werner syndrome is an autosomal recessive disorder characterized by premature aging and cancer predisposition, caused by loss of function mutations in WRN gene. To date, more than 70 different pathogenic variants have been identified… read more here.

Keywords: genetic epigenetic; epigenetic insights; wrn; werner syndrome ... See more keywords

WRN-Mutated Colorectal Cancer Is Characterized by a Distinct Genetic Phenotype

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recommendations! Published in 2020 at "Cancers"

DOI: 10.3390/cancers12051319

Abstract: Werner syndrome gene (WRN) contributes to DNA repair. In cancer, WRN mutations (WRN-mut) lead to genomic instability. Thus, WRN is a promising target in cancers with microsatellite instability (MSI). We assessed this study to investigate… read more here.

Keywords: wrn; colorectal cancer; wrn mut; msi ... See more keywords