WRNIP1 Is Recruited to DNA Interstrand Crosslinks and Promotes Repair
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DOI: 10.1016/j.celrep.2020.107850
Abstract: Summary The Fanconi anemia (FA) pathway repairs DNA interstrand crosslinks (ICLs). Many FA proteins are recruited to ICLs in a timely fashion so that coordinated repair can occur. However, the mechanism of this process is… read more here.
Keywords: wrnip1; interstrand crosslinks; dna interstrand; fancd2 fanci ... See more keywords
WRNIP1 prevents transcription-associated genomic instability
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DOI: 10.1101/2023.06.23.546223
Abstract: R-loops are non-canonical DNA structures that form during transcription and play diverse roles in various physiological processes. Disruption of R-loop homeostasis can lead to genomic instability and replication impairment, contributing to several human diseases, including… read more here.
Keywords: replication; genomic instability; wrnip1; transcription ... See more keywords