Placental Glucose Uptake in a Nonhuman Primate Model of Western-Style Diet Consumption and Chronic Hyperandrogenemia Exposure
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DOI: 10.1007/s43032-021-00526-1
Abstract: We reported that consumption of a western-style diet (WSD) with and without hyperandrogenemia perturbed placental perfusion and altered levels of glucose transporter proteins in rhesus macaques. Based on that result, we hypothesized that placental glucose… read more here.
Keywords: western style; placental glucose; glucose uptake; wsd ... See more keywords
Chronic combined hyperandrogenemia and western-style diet in young female rhesus macaques causes greater metabolic impairments compared to either treatment alone
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DOI: 10.1093/humrep/dex246
Abstract: STUDY QUESTION Does developmental exposure to the combination of hyperandrogenemia and western-style diet (WSD) worsen adult metabolic function compared to either treatment alone? SUMMARY ANSWER Young female rhesus macaques treated for 3 years, beginning at… read more here.
Keywords: treatment; rhesus macaques; female rhesus; wsd ... See more keywords
Chronic hyperandrogenemia in the presence and absence of a western-style diet impairs ovarian and uterine structure/function in young adult rhesus monkeys
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DOI: 10.1093/humrep/dex338
Abstract: STUDY QUESTION Does chronic hyperandrogenemia beginning at menarche, in the absence and presence of a western-style diet (WSD), alter ovarian and uterine structure-function in young adult rhesus monkeys? SUMMARY ANSWER Phenotypic alterations in ovarian and… read more here.
Keywords: function; group; wsd; structure ... See more keywords
Chronic hyperandrogenemia and western-style diet beginning at puberty reduces fertility and increases metabolic dysfunction during pregnancy in young adult, female macaques
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DOI: 10.1093/humrep/dey013
Abstract: STUDY QUESTION What are the impacts of elevated testosterone (T) and an obesogenic western-style diet (WSD), either independently or together, on fertility and metabolic adaptations of pregnancy in primates? SUMMARY ANSWER Testosterone increases the time… read more here.
Keywords: western style; pregnancy; group; wsd ... See more keywords
Maternal high-fat diet consumption and chronic hyperandrogenemia are associated with placental dysfunction in female rhesus macaques.
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DOI: 10.1210/en.2019-00149
Abstract: The risk of adverse perinatal outcomes with maternal polycystic ovarian syndrome may differ among hyperandrogenic and non-hyperandrogenic phenotypes and is likely modulated by both maternal obesity and diet. The relative contribution of maternal hyperandrogenism and… read more here.
Keywords: rhesus macaques; high fat; female rhesus; placental dysfunction ... See more keywords