Wt1 haploinsufficiency induces browning of epididymal fat and alleviates metabolic dysfunction in mice on high-fat diet
Sign Up to like & getrecommendations! Published in 2021 at "Diabetologia"
DOI: 10.1007/s00125-021-05621-1
Abstract: Despite a similar fat storing function, visceral (intra-abdominal) white adipose tissue (WAT) is detrimental, whereas subcutaneous WAT is considered to protect against metabolic disease. Recent findings indicate that thermogenic genes, expressed in brown adipose tissue… read more here.
Keywords: expression; wt1; fat diet; wat ... See more keywords
Identification of two distinct populations of WT1-specific cytotoxic T lymphocytes in co-vaccination of WT1 killer and helper peptides
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-020-02675-9
Abstract: Simultaneous induction of tumor antigen-specific cytotoxic T lymphocytes (CTLs) and helper T lymphocytes (HTLs) is required for an optimal anti-tumor immune response. WT1 332 , a 16-mer WT1-derived helper peptide, induce HTLs in an HLA… read more here.
Keywords: peptide; wt1 specific; wt1 ctl; wt1 ... See more keywords
The role of WT1 isoforms in vasculogenic mimicry and metastatic potential of human triple negative breast cancer cells.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.10.043
Abstract: Triple negative breast cancer (TNBC) is highly aggressive and has a few therapeutic treatments, so new targeted therapy and biomarkers are required to provide alternative choices for treating TNBC patients. Recent studies showed that vasculogenic… read more here.
Keywords: isoform; cell sublines; wt1; tnbc ... See more keywords
Magnesium isoglycyrrhizinate ameliorates fructose-induced podocyte apoptosis through downregulation of miR-193a to increase WT1.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2019.05.016
Abstract: High fructose intake is a risk of glomerular podocyte dysfunction. Podocyte apoptosis has emerged as a major cause of podocyte loss, exacerbating proteinuria. Magnesium isoglycyrrhizinate (MgIG) is usually used as a hepatoprotective agent in clinic.… read more here.
Keywords: podocyte apoptosis; fructose induced; mir 193a; wt1 ... See more keywords
3, 3', 5-Triiodo-L-thyronine affects polarity proteins of bovine Sertoli cells via WT1/non-canonical Wnt signaling pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Theriogenology"
DOI: 10.1016/j.theriogenology.2020.02.034
Abstract: To determine the role of 3, 3', 5-triiodo-L thyroxine (T3) in the differentiation of Sertoli cells (SCs) and the factors influencing maturity via the Wilms' tumor 1 (WT1)/non-canonical Wnt signaling pathway, high purity SCs were… read more here.
Keywords: wnt signaling; wnt; canonical wnt; wt1 non ... See more keywords
WT1 expression associated with platinum-sensitivity and improved progression-free survival in uterine serous carcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Gynecologic Oncology"
DOI: 10.1016/s0090-8258(21)01290-7
Abstract: Objectives: Wilms tumor gene 1 (WT1) expression is a hallmark of ovarian serous carcinoma (OSC) and considered to be diagnostic marker of these tumors, differentiating them from uterine serous carcinoma (USC), traditionally thought to rarely… read more here.
Keywords: platinum sensitivity; wt1; serous carcinoma; expression ... See more keywords
RNA Binding by the KTS Splice Variants of the Wilms' Tumor Suppressor Protein WT1.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemistry"
DOI: 10.1021/acs.biochem.0c00602
Abstract: The Wilms' tumor suppressor protein WT1 regulates the expression of multiple genes through binding of the Cys2-His2 zinc-finger domain to promoter sites. WT1 has also been proposed to be involved in post-transcriptional regulation, by binding… read more here.
Keywords: zinc; splice variants; kts; wt1 ... See more keywords
Prognostic impact of peripheral blood WT1-mRNA expression in patients with MDS
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DOI: 10.1038/s41408-019-0248-y
Abstract: Few reports suggested a prognostic impact of Wilms‘ Tumor-1 (WT1)-mRNA overexpression in MDS, but translation into clinical routine was hampered by limited patients numbers, differing sample sources, non-standardized methods/cut-offs. To evaluate whether WT1-mRNA expression yields… read more here.
Keywords: wt1 mrna; prognostic impact; mrna expression; wt1 ... See more keywords
Overexpression of long non-coding RNA WT1-AS or silencing of PIK3AP1 are inhibitory to cervical cancer progression.
Sign Up to like & getrecommendations! Published in 2021 at "Cell cycle"
DOI: 10.1080/15384101.2021.1991106
Abstract: Accumulating evidence demonstrate that long non-coding RNAs (lncRNAs) play an important role in regulating the biological function of cervical cancer cells. However, the regulatory role of lncRNA Wilms tumor 1 homolog antisense RNA (WT1-AS) in cervical… read more here.
Keywords: rna; cervical cancer; long non; wt1 ... See more keywords
Cellular and Humoral Immune Responses Induced by an HLA Class I–restricted Peptide Cancer Vaccine Targeting WT1 Are Associated With Favorable Clinical Outcomes in Advanced Ovarian Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Immunotherapy (Hagerstown, Md. : 1997)"
DOI: 10.1097/cji.0000000000000405
Abstract: Supplemental Digital Content is available in the text. The HLA-A*24:02–restricted peptide vaccine targeting Wilms’ tumor 1 (WT1) (WT1 vaccine) is a promising therapeutic strategy for ovarian cancer; however, its efficacy varies among patients. In this… read more here.
Keywords: wt1; ovarian cancer; cancer; vaccine ... See more keywords
Significance of WT1 and multiparameter flow cytometry assessment in patients with chronic myelomonocytic leukemia receiving allogeneic hematopoietic stem cell transplantation.
Sign Up to like & getrecommendations! Published in 2022 at "International journal of laboratory hematology"
DOI: 10.1111/ijlh.13788
Abstract: INTRODUCTION The objective of this study was to investigate the clinical significance of minimal residual disease (MRD) monitoring through Wilms tumor 1 (WT1) gene expression and multicolor flow cytometry (FCM) in patients with chronic myelomonocytic… read more here.
Keywords: flow cytometry; hsct; wt1; chronic myelomonocytic ... See more keywords