WT1 mRNA Expression in the Peripheral Blood of Patients with MDS Yields Additional Prognostic Information within the IPSS-R Risk Categories "Very Low", "Low" and "Intermediate"
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DOI: 10.1182/blood-2018-99-113524
Abstract: Introduction: The revised version of the International Prognostic Scoring System, (IPSS-R), is an accepted standard for assessing the prognosis of patients with MDS. Its usefulness may be further improved by integrating molecular findings. However, such… read more here.
Keywords: risk; patients mds; ipss; expression ... See more keywords
Expression of the Tumor Suppressor WT1 Is Induced By PML-Rara in Acute Promyelocytic Leukemia. Â
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DOI: 10.1182/blood.v130.suppl_1.2508.2508
Abstract: Inactivating mutations in Wilms Tumor 1 (WT1) are found in 5-10% of cases of acute myeloid leukemia (AML). Paradoxically, wild type WT1 is expressed highly in most cases of AML compared to normal hematopoietic progenitors,… read more here.
Keywords: pml rara; leukemia; wt1 expression; wt1 ... See more keywords
The assessment of minimal residual disease versus that of somatic mutations for predicting the outcome of acute myeloid leukemia patients
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DOI: 10.1186/s12935-019-0807-0
Abstract: BackgroundIn addition to morphological and cytogenetic features, acute myeloid leukemias are characterized by mutations that can be used for target-therapy; also the minimal/measurable residual disease (MRD) could be an important prognostic factor. The purpose of… read more here.
Keywords: disease; somatic mutations; residual disease; acute myeloid ... See more keywords
Day +60 WT1 assessment on CD34 selected bone marrow better predicts relapse and mortality after allogeneic stem cell transplantation in acute myeloid leukemia patients
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DOI: 10.3389/fonc.2022.994366
Abstract: The aim of this study was to evaluate the role of WT1 expression after allogeneic stem cell transplantation (alloHSCT) in patients with acute myeloid leukemia (AML). We studied WT1 expression in bone marrow cells from… read more here.
Keywords: bone marrow; cd34; wt1 expression; cd34 selected ... See more keywords