WTAP facilitates progression of endometrial cancer via CAV‐1/NF‐κB axis
Sign Up to like & getrecommendations! Published in 2021 at "Cell Biology International"
DOI: 10.1002/cbin.11570
Abstract: The N6‐methyladenosine (m6A) modification is one of the most prevalent methylations in eukaryotic messenger RNA (mRNA), and it is essential for the development of many important biological processes such as multiple types of tumors. One… read more here.
Keywords: facilitates progression; wtap facilitates; endometrial cancer; wtap ... See more keywords
WTAP Promotes Malignant Progression and Immune Escape of Glioblastoma by Regulating N6‐methyladenosine Modification of CENPF
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.70523
Abstract: Glioblastoma (GBM) is a malignant tumor. It has been shown that centromere protein F (CENPF) may serve as a potential prognostic biomarker for glioma patients, while Wilms' tumor 1‐associating protein (WTAP) is frequently upregulated across… read more here.
Keywords: cenpf; immune escape; gbm; progression immune ... See more keywords
Abnormal stress promotes intervertebral disc degeneration through WTAP/YTHDF2‐dependent TIMP3 m6A modification
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.31219
Abstract: Mechanical environment worsening is an important predisposing factor that accelerates intervertebral disc degeneration (IDD), but its specific regulatory mechanisms remain unclear. In this study, we reveal the molecular mechanisms of WTAP/YTHDF2‐mediated m6A modification in abnormal… read more here.
Keywords: abnormal stress; intervertebral disc; timp3; m6a modification ... See more keywords
WTAP contributes to the tumorigenesis of osteosarcoma via modulating ALB in an m6A‐dependent manner
Sign Up to like & getrecommendations! Published in 2023 at "Environmental Toxicology"
DOI: 10.1002/tox.23780
Abstract: Osteosarcoma (OS) is a prevalent bone malignancy mainly occurred in adolescents. WTAP/N6‐methyladenosine (m6A) modification is confirmed to be involved in OS progression. This study is conducted to bring some novel insights to the action mechanism… read more here.
Keywords: wtap; contributes tumorigenesis; wtap contributes; tumorigenesis osteosarcoma ... See more keywords
WTAP Regulates SOX1 Expression to Affect the Tumorigenicity of Colorectal Cancer via an m6A-YTHDF2-Dependent Manner
Sign Up to like & getrecommendations! Published in 2024 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-024-08780-4
Abstract: Wilms tumor 1-associated protein (WTAP) plays a critical role in various cancers, including colorectal cancer (CRC). However, the biological function and molecular mechanisms of WTAP in CRC remain to be elucidated. We determined the expression… read more here.
Keywords: colorectal cancer; sox1; ythdf2; crc ... See more keywords
Tanshinone IIA suppresses the proliferation and fibrosis of mesangial cell in diabetic nephropathy though WTAP-mediated m6A methylation
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-03738-6
Abstract: Diabetic nephropathy (DN) is often accompanied by mesangial cell proliferation and fibrosis. Tanshinone IIA (Tan-IIA) is the main fat-soluble component of Salvia miltiorrhiza. N6-Methyladenosine (m6A) modification is a widely studied epigenetic mechanism. This study aimed… read more here.
Keywords: cell; wtap; proliferation fibrosis; iia ... See more keywords
WTAP-mediated m6A modification regulates NLRP3/Caspase-1/GSDMD to inhibit pyroptosis and exacerbate colorectal cancer.
Sign Up to like & getrecommendations! Published in 2024 at "Biomarkers in medicine"
DOI: 10.1080/17520363.2024.2416886
Abstract: Aim: Wilms' tumor 1-associating protein (WTAP), plays a part in colorectal cancer (CRC) progression. However, it is not yet known how WTAP affects cancer progression by influencing leukocyte rich repeat containing proteins (NLR) - family… read more here.
Keywords: m6a modification; crc; wtap mediated; wtap ... See more keywords
WTAP-Mediated m6A RNA Methylation Regulates the Differentiation of Bone Marrow Mesenchymal Stem Cells via the miR-29b-3p/HDAC4 Axis
Sign Up to like & getrecommendations! Published in 2023 at "Stem Cells Translational Medicine"
DOI: 10.1093/stcltm/szad020
Abstract: Abstract N6-methyladenosine (m6A) methylation, a well-known modification with new epigenetic functions, has been reported to participate in the progression of osteoporosis (OP), providing novel insights into the pathogenesis of OP. However, as the key component… read more here.
Keywords: mir 29b; wtap; methylation; wtap mediated ... See more keywords
WTAP-MEDIATED M6A MODIFICATION OF KLF6 AGGRAVATES HYPOXIA/REOXYGENATION-INDUCED HUMAN CARDIOMYOCYTE INJURY
Sign Up to like & getrecommendations! Published in 2024 at "Shock"
DOI: 10.1097/shk.0000000000002373
Abstract: ABSTRACT Background: Myocardial infarction (MI) is a severe condition that typically results from the ischemia and necrosis of heart muscle. Kruppel-like factor 6 (KLF6) can aggravate myocardial ischemia/reperfusion injury. This work aims to reveal its… read more here.
Keywords: hypoxia reoxygenation; cell; injury; wtap ... See more keywords
WTAP‐Mediated m6A Modification of TRAIL‐DR4 Suppresses MH7A Cell Apoptosis
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Rheumatic Diseases"
DOI: 10.1111/1756-185x.70065
Abstract: N6‐methyladenosine (m6A) is one of the most conserved internal RNA modifications, which has been implicated in many biological processes, such as apoptosis and proliferation. Wilms tumor 1‐associating protein (WTAP), as a key component of m6A… read more here.
Keywords: m6a modification; trail dr4; wtap mediated; wtap ... See more keywords
WTAP mediates IL-1β-induced chondrocyte injury by enhancing CA12 mRNA stability depending on m6A modification
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Orthopaedic Surgery and Research"
DOI: 10.1186/s13018-024-05262-1
Abstract: Osteoarthritis (OA) poses a significant risk to the mobility of patients. Carbonic anhydrase 12 (CA12) can boost apoptosis and inflammation in several cancers, but its role in OA is unknown. Differentially expressed genes in OA… read more here.
Keywords: m6a modification; wtap; depending m6a; apoptosis ... See more keywords