WWOX somatic ablation in skeletal muscles alters glucose metabolism
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2019.01.010
Abstract: Objective WWOX, a well-established tumor suppressor, is frequently lost in cancer and plays important roles in DNA damage response and cellular metabolism. Methods We re-analyzed several genome-wide association studies (GWAS) using the Type 2 Diabetes… read more here.
Keywords: somatic ablation; wwox somatic; metabolism; metabolism wwox ... See more keywords
PARTICLE triplexes cluster in the tumor suppressor WWOX and may extend throughout the human genome
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-07295-5
Abstract: The long non-coding RNA PARTICLE (Gene PARTICL- ‘Promoter of MAT2A-Antisense RadiaTion Induced Circulating LncRNA) partakes in triple helix (triplex) formation, is transiently elevated following low dose irradiation and regulates transcription of its neighbouring gene -… read more here.
Keywords: tumor suppressor; human genome; particle; wwox ... See more keywords
PO-240 WWOX suppressor gene regulate glucose metabolism and warburg effect in case of gestational diabetes mellitusas well as breast cancer
Sign Up to like & getrecommendations! Published in 2018 at "ESMO Open"
DOI: 10.1136/esmoopen-2018-eacr25.273
Abstract: Introduction WWOX gene is a tumour suppressor which loss of expression is demonstrated in many cancers. WWOX is involved in the regulation of glucose metabolism by interaction with HIF1α. WWOX knockdown regulates the metabolic switch… read more here.
Keywords: expression; hif1a; wwox; breast cancer ... See more keywords
VOPP1 promotes breast tumorigenesis by interacting with the tumor suppressor WWOX
Sign Up to like & getrecommendations! Published in 2018 at "BMC Biology"
DOI: 10.1186/s12915-018-0576-6
Abstract: BackgroundThe WW domain-containing oxidoreductase (WWOX) gene, frequently altered in breast cancer, encodes a tumor suppressor whose function is mediated through its interactions with cancer-related proteins, such as the pro-apoptotic protein p73α.ResultsTo better understand the involvement… read more here.
Keywords: tumor suppressor; breast tumorigenesis; vopp1; wwox ... See more keywords
Hyaluronan activates Hyal-2/WWOX/Smad4 signaling and causes bubbling cell death when the signaling complex is overexpressed
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.13268
Abstract: Malignant cancer cells frequently secrete significant amounts of transforming growth factor beta (TGF-β), hyaluronan (HA) and hyaluronidases to facilitate metastasizing to target organs. In a non-canonical signaling, TGF-β binds membrane hyaluronidase Hyal-2 for recruiting tumor… read more here.
Keywords: hyal wwox; wwox smad4; wwox; cell death ... See more keywords
Association between WWOX and the risk of malignant tumor, especially among Asians: evidence from a meta-analysis
Sign Up to like & getrecommendations! Published in 2018 at "OncoTargets and therapy"
DOI: 10.2147/ott.s152140
Abstract: Purpose Many studies have been carried out to examine whether there are associations between WWOX polymorphisms (rs3764340 C>G, rs12918952 G>A, and rs383362 G>T) and malignant tumor risk, but the results from these studies remained inconsistent… read more here.
Keywords: tumor; risk; malignant tumor; wwox ... See more keywords
Cancerous Protein Network That Inhibits the Tumor Suppressor Function of WW Domain-Containing Oxidoreductase (WWOX) by Aberrantly Expressed Molecules
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2018.00350
Abstract: Recent findings indicate that the WW domain-containing oxidoreductase (WWOX) is a tumor suppressor protein that contains two N-terminal WW domains and a central short-chain dehydrogenase/reductase domain. WWOX protein mediates multiple signaling networks that suppress carcinogenesis… read more here.
Keywords: tumor suppressor; protein; domain; wwox ... See more keywords
Therapeutic Zfra4-10 or WWOX7-21 Peptide Induces Complex Formation of WWOX with Selective Protein Targets in Organs that Leads to Cancer Suppression and Spleen Cytotoxic Memory Z Cell Activation In Vivo
Sign Up to like & getrecommendations! Published in 2020 at "Cancers"
DOI: 10.3390/cancers12082189
Abstract: Synthetic Zfra4-10 and WWOX7-21 peptides strongly suppress cancer growth in vivo. Hypothetically, Zfra4-10 binds to the membrane Hyal-2 of spleen Z cells and activates the Hyal-2/WWOX/SMAD4 signaling for cytotoxic Z cell activation to kill cancer… read more here.
Keywords: zfra4 wwox7; zfra4; cell activation; wwox ... See more keywords
WWOX Loses the Ability to Regulate Oncogenic AP-2γ and Synergizes with Tumor Suppressor AP-2α in High-Grade Bladder Cancer
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13122957
Abstract: Simple Summary A prognostic factor of bladder cancer which can benefit from research on molecular markers is the histologic grade. WWOX, AP-2α and AP-2γ are known to have a grade-dependent effect but have not been… read more here.
Keywords: bladder cancer; grade; grade bladder; wwox ... See more keywords
Wwox Binding to the Murine Brca1-BRCT Domain Regulates Timing of Brip1 and CtIP Phospho-Protein Interactions with This Domain at DNA Double-Strand Breaks, and Repair Pathway Choice
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23073729
Abstract: Wwox-deficient human cells show elevated homologous recombination, leading to resistance to killing by double-strand break-inducing agents. Human Wwox binds to the Brca1 981-PPLF-984 Wwox-binding motif, likely blocking the pChk2 phosphorylation site at Brca1-S988. This phosphorylation… read more here.
Keywords: brca1; wwox; ctip; double strand ... See more keywords
Zfra Inhibits the TRAPPC6AΔ-Initiated Pathway of Neurodegeneration
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232314510
Abstract: When WWOX is downregulated in middle age, aggregation of a protein cascade, including TRAPPC6AΔ (TPC6AΔ), TIAF1, and SH3GLB2, may start to occur, and the event lasts more than 30 years, which results in amyloid precursor… read more here.
Keywords: month old; aggregation; wwox; neurodegeneration ... See more keywords