Identification of WWP1 as an obesity-associated E3 ubiquitin ligase with a protective role against oxidative stress in adipocytes.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.11.127
Abstract: White adipose tissue (WAT) is not only the main tissue for energy storage but also an endocrine organ that secretes adipokines. Obesity is the most common metabolic disorder and is related to alterations in WAT… read more here.
Keywords: ubiquitin ligase; wwp1; obesity; ligase ... See more keywords
Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway
Sign Up to like & getrecommendations! Published in 2019 at "Science"
DOI: 10.1126/science.aau0159
Abstract: Supporting tumor suppression The protein PTEN is a phosphatase and tumor suppressor whose activity is often decreased in human cancers. Thus, reactivating such a protein could potentially be an effective therapy against cancer. Lee et… read more here.
Keywords: tumor suppressor; wwp1; cancer; myc ... See more keywords
Targeting E3 Ubiquitin Ligase WWP1 Prevents Cardiac Hypertrophy Through Destabilizing DVL2 via Inhibition of K27-Linked Ubiquitination
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DOI: 10.1161/circulationaha.121.054827
Abstract: Supplemental Digital Content is available in the text. Background: Without adequate treatment, pathological cardiac hypertrophy induced by sustained pressure overload eventually leads to heart failure. WWP1 (WW domain–containing E3 ubiquitin protein ligase 1) is an… read more here.
Keywords: hypertrophy; k27 linked; wwp1; heart ... See more keywords