WWP2 overexpression inhibits the antitumor effects of doxorubicin in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11856
Abstract: Hepatocellular carcinoma (HCC) is a common liver cancer that accounts for 90% of cases. Doxorubicin exhibits a broad spectrum of antitumor activity and is one of the most active agents in HCC. WW domain‐containing protein… read more here.
Keywords: wwp2 overexpression; hepatocellular carcinoma; effects doxorubicin; wwp2 ... See more keywords
Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-26653-6
Abstract: The pluripotency transcription factor SOX2 is essential for the maintenance of glioblastoma stem cells (GSC), which are thought to underlie tumor growth, treatment resistance, and recurrence. To understand how SOX2 is regulated in GSCs, we… read more here.
Keywords: binding ligases; wwp2; sox2; ligases trim26 ... See more keywords
Expanding the inhibitor space of the WWP1 and WWP2 HECT E3 ligases
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2024.2394895
Abstract: Abstract The HECT E3 ubiquitin ligases 1 (WWP1) and 2 (WWP2) are responsible for the ubiquitin-mediated degradation of key tumour suppressor proteins and are dysregulated in various cancers and diseases. Here we expand their limited… read more here.
Keywords: inhibitor space; hect; wwp2; wwp1 wwp2 ... See more keywords
miR-328-5p Induces Human Intervertebral Disc Degeneration by Targeting WWP2
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/3511967
Abstract: Intervertebral disc degeneration (IDD) development is regulated by miRNA, including inflammatory reactions, cell apoptosis, and degradation of extracellular matrix. Nucleus pulposus cells apoptosis has a absolute influence in the development of IDD. This experiment explores… read more here.
Keywords: degeneration; mir 328; mir; wwp2 ... See more keywords
Abstract 264: The E3 ubiquitin ligase WWP2 regulates stability of the chromatin remodeler ARID1B
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-264
Abstract: The Switch/sucrose-non-fermentable (SWI/SNF; also known as BRG1 associated factors (BAF)) chromatin remodeling complex functions to slide/evict nucleosomes thus making DNA available for multiple DNA-protein interactions to facilitate cardinal nuclear processes. Work during past two decades… read more here.
Keywords: cancer; stability; arid1b; arid1b protein ... See more keywords
WWP2 Promotes Odontoblastic Differentiation by Monoubiquitinating KLF5
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Dental Research"
DOI: 10.1177/0022034520970866
Abstract: WW domain-containing E3 Ub-protein ligase 2 (WWP2) belongs to the homologous to E6AP C-terminus (HECT) E3 ligase family. It has been explored to regulate osteogenic differentiation, chondrogenesis, and palatogenesis. Odontoblasts are terminally differentiated mesenchymal cells,… read more here.
Keywords: wwp2; differentiation; odontoblastic differentiation; differentiation monoubiquitinating ... See more keywords