WWP2 overexpression inhibits the antitumor effects of doxorubicin in hepatocellular carcinoma
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DOI: 10.1002/cbin.11856
Abstract: Hepatocellular carcinoma (HCC) is a common liver cancer that accounts for 90% of cases. Doxorubicin exhibits a broad spectrum of antitumor activity and is one of the most active agents in HCC. WW domain‐containing protein… read more here.
Keywords: wwp2 overexpression; hepatocellular carcinoma; effects doxorubicin; wwp2 ... See more keywords
Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma
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DOI: 10.1038/s41467-021-26653-6
Abstract: The pluripotency transcription factor SOX2 is essential for the maintenance of glioblastoma stem cells (GSC), which are thought to underlie tumor growth, treatment resistance, and recurrence. To understand how SOX2 is regulated in GSCs, we… read more here.
Keywords: binding ligases; wwp2; sox2; ligases trim26 ... See more keywords
miR-328-5p Induces Human Intervertebral Disc Degeneration by Targeting WWP2
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DOI: 10.1155/2022/3511967
Abstract: Intervertebral disc degeneration (IDD) development is regulated by miRNA, including inflammatory reactions, cell apoptosis, and degradation of extracellular matrix. Nucleus pulposus cells apoptosis has a absolute influence in the development of IDD. This experiment explores… read more here.
Keywords: degeneration; mir 328; mir; wwp2 ... See more keywords
WWP2 Promotes Odontoblastic Differentiation by Monoubiquitinating KLF5
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DOI: 10.1177/0022034520970866
Abstract: WW domain-containing E3 Ub-protein ligase 2 (WWP2) belongs to the homologous to E6AP C-terminus (HECT) E3 ligase family. It has been explored to regulate osteogenic differentiation, chondrogenesis, and palatogenesis. Odontoblasts are terminally differentiated mesenchymal cells,… read more here.
Keywords: wwp2; differentiation; odontoblastic differentiation; differentiation monoubiquitinating ... See more keywords