Design, synthesis, and biological evaluation of a potent PLK4 inhibitor WY29 with 1H‐pyrazolo[3,4‐d]pyrimidine scaffold
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DOI: 10.1002/ardp.202200490
Abstract: Centriole duplication occurs once per cell cycle and is regulated by Polo‐like kinase 4 (PLK4). Overexpression of PLK4 in somatic cells can lead to the excessive formation of centrioles, directly causing chromosome segregation errors and… read more here.
Keywords: compound; wy29; pyrazolo pyrimidine; plk4 ... See more keywords