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Published in 2019 at "Annals of Oncology"
DOI: 10.1093/annonc/mdz238.022
Abstract: Abstract Background X-linked inhibitor of apoptosis (XIAP)-associated factor 1 (XAF1) is a tumor suppressor that is frequently lost or down-regulated by aberrant promoter hypermethylation in multiple human cancers. To explore XAF1’s candidacy for a suppressor…
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Keywords:
xaf1;
brca1 mediated;
apoptosis;
estrogen ... See more keywords
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Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.00774-22
Abstract: Rapid and robust induction of antiviral genes is essential for the host to clear the invaded viruses. In addition to the IRF3/7-IFN-I-STAT1 signaling axis, the XAF1-IRF1 positive feedback loop synergistically or independently drives the transcription…
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Keywords:
irf1;
host;
antiviral immunity;
xaf1 ... See more keywords
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Published in 2022 at "EMBO reports"
DOI: 10.15252/embr.202255387
Abstract: Interferon regulatory factor (IRF) 3 and IRF7 are master regulators of type I interferon (IFN‐I)‐dependent antiviral innate immunity. Upon viral infection, a positive feedback loop is formed, wherein IRF7 promotes further induction of IFN‐I in…
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Keywords:
viral infection;
upon viral;
interferon;
xaf1 ... See more keywords
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Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.14748
Abstract: XAF1 (X-linked inhibitor of apoptosis (XIAP)-associated factor 1) is a tumor suppressor that counteracts the anti-apoptotic effects of XIAP and can sensitize cells to cell death triggering events. XAF1 knockdown abrogated the temozolomide (TMZ)-induced G2-arrest…
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Keywords:
xaf1;
methylation;
gliomas;
high grade ... See more keywords
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Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24032476
Abstract: Due to their therapeutic potential, mesenchymal stem cells are the subject of intensive research on the use of their potential in the treatment of, among others, neurodegenerative diseases or immunological diseases. They are among the…
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Keywords:
family;
expression;
milk;
stem cells ... See more keywords