Xanthoceraside administration produces significant antidepressant effects in mice through activation of the hippocampal BDNF signaling pathway
Sign Up to like & getrecommendations! Published in 2021 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2021.135994
Abstract: Current available antidepressants have various adverse reactions and slow pharmacodynamics, so it is necessary to find novel antidepressants for effective treatment. Xanthoceraside (XAN), a novel triterpenoid saponin extracted from the fruit husks of Xanthoceras sorbifolium… read more here.
Keywords: effects mice; xan; signaling pathway; bdnf signaling ... See more keywords
Xanthohumol suppresses NPC1L1 gene expression through down-regulation of HNF-4α and inhibits cholesterol uptake in Caco-2 cells.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.9b05221
Abstract: Xanthohumol (Xan) is a prenylated chalcone mainly found in hops, it has been demonstrated to function against hypercholesterolemia, hyperlipidemia, and atherosclerosis. In this study, we focused on the hypocholesterolemic effect of Xan on cholesterol uptake… read more here.
Keywords: caco cells; xan; hnf; expression ... See more keywords