Binding Modes of Xanthine‐Derived Selective Allosteric Site Inhibitors of MTHFD2
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DOI: 10.1002/open.202300052
Abstract: Abstract Methylenetetrahydrofolate dehydrogenase (MTHFD2) is a mitochondrial enzyme involved in 1 C metabolism that is upregulated in various cancer cells, but absent in normal proliferating cells. Xanthine derivatives are the first selective inhibitors of MTHFD2 which… read more here.
Keywords: xanthine derivatives; allosteric site; modes xanthine; inhibitors mthfd2 ... See more keywords
Design, synthesis and biological evaluation of novel 1,2,3-triazole-based xanthine derivatives as DPP-4 inhibitors
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DOI: 10.1007/s12039-020-1760-0
Abstract: Abstract Inhibitors of dipeptidyl peptidase-4 (DPP4) have been shown to be effective treatments for type 2 diabetes. A series of novel 1,2,3-triazole based xanthine derivatives were designed and evaluated for in vitro dipeptidyl peptidase-4 (DPP-4)… read more here.
Keywords: based xanthine; xanthine derivatives; dpp inhibitors; triazole based ... See more keywords
Synthesis, Crystal Structures, and Biological Activity Evaluation of Novel Xanthine Derivatives Containing a Pyrethroid Moiety.
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DOI: 10.1021/acs.jafc.2c03876
Abstract: On the basis of the structures of natural xanthines and pyrethroid insecticides, a series of novel xanthine derivatives Ia-Is containing pyrethroid motifs were synthesized and identified by means of melting points, 1H NMR, 13C NMR,… read more here.
Keywords: xanthine derivatives; chemistry; derivatives containing; novel xanthine ... See more keywords
Formulation and Characterization of New Polymeric Systems Based on Chitosan and Xanthine Derivatives with Thiazolidin-4-One Scaffold
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DOI: 10.3390/ma12040558
Abstract: In the past many research studies have focused on the thiazolidine-4-one scaffold, due to the important biological effects associated with its heterocycle. This scaffold is present in the structure of many synthetic compounds, which showed… read more here.
Keywords: thiazolidine one; xanthine derivatives; candida; polymeric systems ... See more keywords