2‐Benzamido‐4‐methylthiazole‐5‐carboxylic Acid Derivatives as Potential Xanthine Oxidase Inhibitors and Free Radical Scavengers
Sign Up to like & getrecommendations! Published in 2017 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.201600313
Abstract: The new chemical entities febuxostat and topiroxostat have been approved by the US Food and Drug Administration, opening new avenues for exploiting different heterocycles other than purines as xanthine oxidase (XO) inhibitors. A different series… read more here.
Keywords: xanthine oxidase; carboxylic acid; benzamido methylthiazole; methylthiazole carboxylic ... See more keywords
Xanthine oxidase inhibition for the treatment of cardiovascular disease: an updated systematic review and meta‐analysis
Sign Up to like & getrecommendations! Published in 2017 at "ESC Heart Failure"
DOI: 10.1002/ehf2.12112
Abstract: Previous studies have shown that xanthine oxidase inhibitors (XOI) might improve outcome for patients with cardiovascular disease. However, more evidence is required. read more here.
Keywords: cardiovascular disease; inhibition treatment; xanthine oxidase; oxidase inhibition ... See more keywords
Study on the spectrum-effect relationship of the xanthine oxidase inhibitory activity of Ligustrum lucidum.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of separation science"
DOI: 10.1002/jssc.201900531
Abstract: To evaluate the xanthine oxidase inhibitory activity of the chemical constituents of Ligustrum lucidum in vitro, the spectrum-effect relationship was investigated. The HPLC fingerprint was established by ultraviolet spectrophotometry, and the xanthine oxidase inhibitory activity… read more here.
Keywords: xanthine oxidase; ligustrum lucidum; spectrum effect; activity ... See more keywords
Screening anti-gout compounds from Phellinus igniarius by ultrafiltration LC-MS based on evaluation of an in vitro method combined with enzymatic reaction.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of separation science"
DOI: 10.1002/jssc.202100109
Abstract: In the present study, the anti-inflammation effect of Phellinus igniarius extract was detected on an in vitro model of, RAW 264.7 cells stimulated using sodium urate. In this cell model, the content changes of inflammatory… read more here.
Keywords: xanthine oxidase; phellinus igniarius; igniarius ultrafiltration; compounds phellinus ... See more keywords
Design, synthesis and biological evaluation of novel indolinedione–coumarin hybrids as xanthine oxidase inhibitors
Sign Up to like & getrecommendations! Published in 2020 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-020-02589-2
Abstract: A library of indolinedione–coumarin hybrid molecules was rationally designed and synthesized against hyperuricemia. All of the synthesized hybrid molecules were tested to check their inhibitory activity against xanthine oxidase enzyme by using a spectrophotometric assay.… read more here.
Keywords: oxidase enzyme; oxidase; xanthine oxidase; indolinedione coumarin ... See more keywords
Allopurinol protects human glomerular endothelial cells from high glucose-induced reactive oxygen species generation, p53 overexpression and endothelial dysfunction
Sign Up to like & getrecommendations! Published in 2017 at "International Urology and Nephrology"
DOI: 10.1007/s11255-017-1733-5
Abstract: PurposeMitochondrial reactive oxygen species (ROS) overproduction in capillary endothelial cells is a prerequisite for the development of diabetic nephropathy. Inhibition of xanthine oxidase, another ROS generator, ameliorates experimental diabetic nephropathy. To test the hypothesis that… read more here.
Keywords: xanthine oxidase; high glucose; p53; endothelial dysfunction ... See more keywords
A flavonoid-rich fraction of Monolluma quadrangula inhibits xanthine oxidase and ameliorates potassium oxonate-induced hyperuricemia in rats
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-022-20274-2
Abstract: Hyperuricemia represents a risk factor for the progression of chronic kidney disease. Oxidative stress and inflammation are implicated in the mechanisms underlying hyperuricemia-mediated kidney injury. Monolluma quadrangula possesses several beneficial effects; however, its effect on… read more here.
Keywords: potassium oxonate; activity; xanthine oxidase; monolluma quadrangula ... See more keywords
Xanthine oxidase inhibitors in elderly patients with heart failure: useful or useless?
Sign Up to like & getrecommendations! Published in 2019 at "Internal and Emergency Medicine"
DOI: 10.1007/s11739-019-02105-4
Abstract: Elevated serum uric acid levels have been progressively emerged as a powerful and independent risk factor for many cardiovascular diseases, including hypertension [1, 2], coronary artery disease [3, 4], stroke [5, 6] and congestive heart… read more here.
Keywords: uric acid; xanthine oxidase; heart; serum ... See more keywords
Amide-based xanthine oxidase inhibitors bearing an N-(1-alkyl-3-cyano-1H-indol-5-yl) moiety: Design, synthesis and structure-activity relationship investigation.
Sign Up to like & getrecommendations! Published in 2021 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2021.105417
Abstract: Our previous work identified a promising isonicotinamide based xanthine oxidase (XO) inhibitor, N-(3-cyano-4-((2-cyanobenzyl)oxy)phenyl)isonicotinamide (1), and concluded that amide is an effective linker in exploring the XO inhibitor chemical space that is completely different from the… read more here.
Keywords: amide based; xanthine oxidase; based xanthine; cyano indol ... See more keywords
Sodium acetate protects against nicotine-induced excess hepatic lipid in male rats by suppressing xanthine oxidase activity.
Sign Up to like & getrecommendations! Published in 2019 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2019.108929
Abstract: Fatty liver is the hepatic consequence of chronic insulin resistance (IR) and related syndromes. It is mostly accompanied by inflammatory and oxidative molecules. Increased activity of xanthine oxidase (XO) exerts both inflammatory and oxidative effects… read more here.
Keywords: xanthine oxidase; nicotine induced; acetate; sodium acetate ... See more keywords
Design, synthesis and biological evaluation of 1-hydroxy-2-phenyl-4-pyridyl-1H-imidazole derivatives as xanthine oxidase inhibitors.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.01.060
Abstract: In our previous study, we reported a series of 1-hydroxy-2-phenyl-1H-imidazole-5-carboxylic acid derivatives that presented excellent in vitro xanthine oxidase inhibitory potency. As a continuation study, a series of 1-hydroxy-2-phenyl-1H-imidazole derivatives containing a pyridine moiety (4a-g and… read more here.
Keywords: xanthine oxidase; imidazole derivatives; series; oxidase inhibitors ... See more keywords