Inhibition of the IRE-1α/XBP-1 pathway prevents chronic GVHD and preserves the GVL effect in mice.
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DOI: 10.1182/bloodadvances.2017009068
Abstract: Hematopoietic stem cell transplantation (HCT) is a curative procedure for hematological malignancies, but chronic graft-versus-host disease (cGVHD) remains a major complication after allogeneic HCT. Because donor B cells are essential for cGVHD development and B… read more here.
Keywords: xbp pathway; ire xbp; cell; cgvhd ... See more keywords