XBP1 inhibits mesangial cell apoptosis in response to oxidative stress via the PTEN/AKT pathway in diabetic nephropathy
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12655
Abstract: Diabetic nephropathy (DN) is a complication of diabetes mellitus (DM) that frequently results in renal disease, and is characterized by a variety of symptoms, including albuminuria. It has been shown that apoptosis of glomerular mesangial… read more here.
Keywords: pten akt; apoptosis; oxidative stress; cell apoptosis ... See more keywords
The interaction between XBP1 and eNOS contributes to endothelial cell migration
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2018.01.016
Abstract: Abstract The X‐box binding protein 1 (XBP1) is a pivotal transcription factor in the endoplasmic reticulum stress response. Our previous studies have proven that XBP1 is involved in vascular endothelial growth factor (VEGF)‐mediated endothelial cell… read more here.
Keywords: xbp1s; endothelial cell; migration; nitric oxide ... See more keywords
Regulated IRE1-dependent mRNA decay sets the threshold for dendritic cell survival
Sign Up to like & getrecommendations! Published in 2017 at "Nature Cell Biology"
DOI: 10.1038/ncb3518
Abstract: The IRE1–XBP1 signalling pathway is part of a cellular programme that protects against endoplasmic reticulum (ER) stress, but also controls development and survival of immune cells. Loss of XBP1 in splenic type 1 conventional dendritic… read more here.
Keywords: cell survival; regulated ire1; ire1 dependent; cell ... See more keywords
Hepatocyte-specific deletion of XBP1 sensitizes mice to liver injury through hyperactivation of IRE1α.
Sign Up to like & getrecommendations! Published in 2020 at "Cell death and differentiation"
DOI: 10.1038/s41418-020-00671-1
Abstract: X-box binding protein-1 (XBP1) is a transcription factor that plays a central role in controlling cellular responses to endoplasmic reticulum (ER) stress. Under stress conditions, the transcriptionally active form of XBP1 is generated via splicing… read more here.
Keywords: xbp1 hep; deletion; mice; liver injury ... See more keywords
Porphyromonas gingivalis lipopolysaccharide (Pg-LPS) influences adipocytes injuries through triggering XBP1 and activating mitochondria-mediated apoptosis
Sign Up to like & getrecommendations! Published in 2021 at "Adipocyte"
DOI: 10.1080/21623945.2020.1856527
Abstract: ABSTRACT Obesity is an important public-health problem worldwide. This study aimed to determine effects of porphyromonas gingivalis lipopolysaccharide (Pg-LPS) on adipocytes injuries and explore associated mechanisms. Adipocytes were isolated from SD rats. pLVX-XBP1 (XBP1 over-expression)… read more here.
Keywords: adipocytes injuries; porphyromonas gingivalis; lipopolysaccharide lps; expression ... See more keywords
Identification of XBP1-u as a novel regulator of the MDM2/p53 axis using an shRNA library
Sign Up to like & getrecommendations! Published in 2017 at "Science Advances"
DOI: 10.1126/sciadv.1701383
Abstract: The unspliced form of XBP1 stabilizes MDM2 protein by inhibiting its ubiquitination and regulates the MDM2/p53 axis. Cell cycle progression is a tightly controlled fundamental process in living cells, with any defects being closely linked… read more here.
Keywords: p53 axis; p53; regulator; mdm2 p53 ... See more keywords
Rotavirus Infection Alters Splicing of the Stress-Related Transcription Factor XBP1
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Virology"
DOI: 10.1128/jvi.01739-18
Abstract: Rotavirus is one of the most important pathogens causing severe gastroenteritis in young children worldwide. Here we show that infection with several rotavirus strains induces an alternative splicing of the RNA encoding the stressed-induced transcription… read more here.
Keywords: rotavirus; infection; transcription factor; xbp1 ... See more keywords
XBP1-Mediated BiP/GRP78 Upregulation Copes with Oxidative Stress in Mosquito Cells during Dengue 2 Virus Infection
Sign Up to like & getrecommendations! Published in 2017 at "BioMed Research International"
DOI: 10.1155/2017/3519158
Abstract: Dengue viruses (DENVs) cause dengue fever which is an important mosquito-borne disease in tropical areas. Generally, DENV does not cause cellular damage in mosquito cells. However, alterations in cytosolic calcium ions ([Ca2+]cyt) and the mitochondrial… read more here.
Keywords: mosquito; bip grp78; oxidative stress; infection ... See more keywords
A Human Genome-Wide RNAi Screen Reveals Diverse Modulators that Mediate IRE1α–XBP1 Activation
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Cancer Research"
DOI: 10.1158/1541-7786.mcr-17-0307
Abstract: Activation of the unfolded protein response (UPR) signaling pathways is linked to multiple human diseases, including cancer. The inositol-requiring kinase 1α (IRE1α)–X-box binding protein 1 (XBP1) pathway is the most evolutionarily conserved of the three… read more here.
Keywords: ire1 xbp1; genome wide; wide rnai; screen ... See more keywords
Impairment of both IRE1 expression and XBP1 activation is a hallmark of GCB DLBCL and contributes to tumor growth.
Sign Up to like & getrecommendations! Published in 2017 at "Blood"
DOI: 10.1182/blood-2016-09-741348
Abstract: The endoplasmic reticulum kinase inositol-requiring enzyme 1 (IRE1) and its downstream target X-box-binding protein 1 (XBP1) drive B-cell differentiation toward plasma cells and have been shown to contribute to multiple myeloma development; yet, little is… read more here.
Keywords: dlbcl; ire1 expression; gcb dlbcl; tumor growth ... See more keywords
Loss of XBP1 accelerates age-related decline in retinal function and neurodegeneration
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Neurodegeneration"
DOI: 10.1186/s13024-018-0250-z
Abstract: BackgroundAging is the strongest risk factor for neurodegenerative diseases and extended age results in neuronal degeneration and functional decline in the visual system. Among many contributing factors to age-related deterioration of neurons is an insufficient… read more here.
Keywords: age related; age; neurodegeneration; mice ... See more keywords