Hepatocyte-specific deletion of XBP1 sensitizes mice to liver injury through hyperactivation of IRE1α.
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DOI: 10.1038/s41418-020-00671-1
Abstract: X-box binding protein-1 (XBP1) is a transcription factor that plays a central role in controlling cellular responses to endoplasmic reticulum (ER) stress. Under stress conditions, the transcriptionally active form of XBP1 is generated via splicing… read more here.
Keywords: xbp1 hep; deletion; mice; liver injury ... See more keywords