Endoplasmic Reticulum Stress Contributes to Copper-Induced Pyroptosis via Regulating the IRE1α-XBP1 Pathway in Pig Jejunal Epithelial Cells.
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DOI: 10.1021/acs.jafc.1c07927
Abstract: Copper (Cu) is a common additive in food products, which poses a potential concern to animal and human health when it is in excess. Here, we investigated the relationship between endoplasmic reticulum (ER) stress and… read more here.
Keywords: stress; induced pyroptosis; ire1 xbp1; pyroptosis ... See more keywords
Genome-wide analyses reveal the IRE1a-XBP1 pathway promotes T helper cell differentiation by resolving secretory stress and accelerating proliferation
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DOI: 10.1186/s13073-018-0589-3
Abstract: BackgroundThe IRE1a-XBP1 pathway is a conserved adaptive mediator of the unfolded protein response. The pathway is indispensable for the development of secretory cells by facilitating protein folding and enhancing secretory capacity. In the immune system,… read more here.
Keywords: xbp1 pathway; helper cell; ire1a xbp1; xbp1 ... See more keywords
Inositol-requiring enzyme 1α/X-box protein 1 pathway expression is impaired in pediatric cholestatic liver disease explants
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DOI: 10.1371/journal.pone.0279016
Abstract: Background Increased intrahepatic bile acids cause endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) is activated to maintain homeostasis. UPR dysregulation, including the inositol-requiring enzyme 1α/X-box protein 1 (IRE1α/XBP1) pathway, is associated with… read more here.
Keywords: liver; ire1 xbp1; disease; expression ... See more keywords