Constitutive expression of spliced XBP1 causes perinatal lethality in mice
Sign Up to like & getrecommendations! Published in 2021 at "genesis"
DOI: 10.1002/dvg.23420
Abstract: Upon endoplasmic reticulum (ER) stress, inositol‐requiring enzyme 1 (IRE1) is activated and catalyzes nonconventional splicing of an unspliced X‐box binding protein 1 (XBP1U) mRNA to yield a spliced XBP1 (XBP1S) mRNA that encodes a potent… read more here.
Keywords: spliced xbp1; xbp1s; xbp1cs; twist2 cre ... See more keywords
Expression of XBP1s in fibroblasts is critical for TiAl6V4 particle‐induced RANKL expression and osteolysis
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Orthopaedic Research"
DOI: 10.1002/jor.23056
Abstract: Wear particle‐induced osteolysis is a major cause of aseptic loosening, which is one of the most common reasons for total hip arthroplasty (THA) failure. Previous studies have shown that the expression of Receptor activation of… read more here.
Keywords: xbp1s; particle induced; osteolysis; expression ... See more keywords
The interaction between XBP1 and eNOS contributes to endothelial cell migration
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2018.01.016
Abstract: Abstract The X‐box binding protein 1 (XBP1) is a pivotal transcription factor in the endoplasmic reticulum stress response. Our previous studies have proven that XBP1 is involved in vascular endothelial growth factor (VEGF)‐mediated endothelial cell… read more here.
Keywords: xbp1s; endothelial cell; migration; nitric oxide ... See more keywords
Pivotal role of the endoplasmic reticulum stress-related XBP1s/miR-22/SIRT1 axis in acute myeloid leukemia apoptosis and response to chemotherapy
Sign Up to like & getrecommendations! Published in 2024 at "Leukemia"
DOI: 10.1038/s41375-024-02321-8
Abstract: Malignant growth relies on rapid protein synthesis frequently leading to endoplasmic reticulum (ER) overload and accumulation of unfolded or misfolded protein in this cellular compartment. In the ER, protein homeostasis is finely regulated by a… read more here.
Keywords: xbp1s; acute myeloid; response; endoplasmic reticulum ... See more keywords
ERS regulates endometrial epithelial cell autophagy through XBP1s-mediated activation of the PI3K/AKT pathway
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-024-84461-6
Abstract: Autophagy is a fundamental cellular activity involved in the renewal of cellular components, occurring primarily in cells subjected to physiological remodeling or pathological stimuli. The occurrence of autophagy is closely related to the endoplasmic reticulum… read more here.
Keywords: xbp1s; endometrial epithelial; akt pathway; expression ... See more keywords
Xbp1s-Ddit3 promotes MCT-induced pulmonary hypertension.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical science"
DOI: 10.1042/cs20210612
Abstract: Pulmonary hypertension (PH) is a life-threatening disease characterized by vascular remodeling. Exploring new therapy target is urgent. The purpose of this study is to investigate whether and how spliced x-box binding protein 1 (xbp1s), a… read more here.
Keywords: protein; pulmonary hypertension; xbp1s; mct induced ... See more keywords
Disruption of IRE1α through its kinase domain attenuates multiple myeloma
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1906999116
Abstract: Significance Multiple myeloma (MM) is a lethal malignancy arising from plasma cells. MM cells experience endoplasmic reticulum (ER) stress due to immunoglobulin hyperproduction. The ER-resident sensor IRE1α mitigates ER stress by expanding protein-folding and secretion… read more here.
Keywords: xbp1s; kinase; multiple myeloma; ire1 kinase ... See more keywords
Kai-Xin-San improves cognitive impairment via Wnt/β-catenin and IRE1/XBP1s signalings in APP/PS1 mice.
Sign Up to like & getrecommendations! Published in 2023 at "Rejuvenation research"
DOI: 10.1089/rej.2022.0063
Abstract: Alzheimer's disease (AD) is the most common type of dementia with an insidious onset and slow progression. Kai-Xin-San (KXS) has been reported to be effective in improving cognitive impairment in AD. However, the mechanism is… read more here.
Keywords: app ps1; xbp1s; ire1; mice ... See more keywords
Involvement of XBP1s in Blue Light-Induced A2E-Containing Retinal Pigment Epithelium Cell Death
Sign Up to like & getrecommendations! Published in 2017 at "Ophthalmic Research"
DOI: 10.1159/000452282
Abstract: Purpose: Retinal pigment epithelium (RPE) cell dysfunction is essential to the development of retinal degenerative disease. This study was designed to investigate how spliced X-box-binding protein 1 (XBP1s) regulates different modes of RPE cell death… read more here.
Keywords: blue light; xbp1s; cell death; retinal pigment ... See more keywords
Spliced X-Box Binding Protein 1 Stimulates Adaptive Growth Through Activation of mTOR.
Sign Up to like & getrecommendations! Published in 2019 at "Circulation"
DOI: 10.1161/circulationaha.118.038924
Abstract: BACKGROUND The unfolded protein response (UPR) plays versatile roles in physiology and pathophysiology. Its connection to cell growth however remains elusive. Here, we sought to define the role of UPR in regulation of cardiomyocyte growth… read more here.
Keywords: activation; xbp1s; growth; mtor ... See more keywords
Nuclear expression of XBP1s is correlated with breast cancer survival: a retrospective analysis based on tissue microarray
Sign Up to like & getrecommendations! Published in 2017 at "OncoTargets and therapy"
DOI: 10.2147/ott.s147102
Abstract: An alternatively spliced transcription factor that participates in the unfolded protein response, XBP1 is a novel protein involved in cancer progression and outcome. This study aimed to investigate the relationship of spliced XBP1 (XBP1s) with… read more here.
Keywords: expression xbp1s; expression; xbp1s; breast cancer ... See more keywords