NR4A1 Exerts Pro-Tumor Role in Glioblastoma via Inducing xCT/GPX4-Regulated Ferroptosis.
Sign Up to like & getrecommendations! Published in 2025 at "Annals of clinical and translational neurology"
DOI: 10.1002/acn3.70173
Abstract: PURPOSE This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor… read more here.
Keywords: xct; xct gpx4; ferroptosis; tumor ... See more keywords
Triptolide Promotes Ferroptosis in Cervical Cancer Cell via NRF2/xCT/GPX4
Sign Up to like & getrecommendations! Published in 2024 at "Phytotherapy Research"
DOI: 10.1002/ptr.8398
Abstract: Cervical cancer (CC) is a serious risk to women's health; it is necessary to explore less toxic and more effective therapies to cure CC. Triptolide (Tri) is the principal active constituent found in “Tripterygium Wilford,”… read more here.
Keywords: ferroptosis cells; gpx4 xct; xct; cervical cancer ... See more keywords
High expression of cystine–glutamate antiporter xCT (SLC7A11) is an independent biomarker for epileptic seizures at diagnosis in glioma
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-018-2785-9
Abstract: Epileptic seizures are an important cause of morbidity in glioma patients. Substantial lines of evidence support the concept of the excitatory neurotransmitter glutamate being a crucial mediator of glioma-associated seizures. In gliomas, non-vesicular secretion of… read more here.
Keywords: xct expression; xct; glioma; expression ... See more keywords
Semi-quantitative distribution of excitatory amino acid (glutamate) transporters 1–3 (EAAT1-3) and the cystine-glutamate exchanger (xCT) in the adult murine spinal cord
Sign Up to like & getrecommendations! Published in 2020 at "Neurochemistry International"
DOI: 10.1016/j.neuint.2020.104811
Abstract: Proper glutamatergic neurotransmission requires a balance between glutamate release and removal. The removal is mainly catalyzed by the glutamate transporters EAAT1-3, while the glutamate-cystine exchanger (system xc- with specific subunit xCT) represents one of the… read more here.
Keywords: xct; glutamate transporters; glutamate; distribution ... See more keywords
xCT/SLC7A11 antiporter function inhibits HIV-1 infection.
Sign Up to like & getrecommendations! Published in 2021 at "Virology"
DOI: 10.1016/j.virol.2021.01.008
Abstract: Human macrophages are protected by intrinsic antiviral defenses that provide moderate protection against HIV-1 infection. Macrophages that do become infected can serve as long-lived reservoirs, to disseminate HIV-1 to CD4+ T cells. Infection of macrophages… read more here.
Keywords: hiv infection; xct; xct slc7a11; antiporter ... See more keywords
Implication of the glutamate–cystine antiporter xCT in schizophrenia cases linked to impaired GSH synthesis
Sign Up to like & getrecommendations! Published in 2017 at "NPJ Schizophrenia"
DOI: 10.1038/s41537-017-0035-3
Abstract: AbstractxCT is the specific chain of the cystine/glutamate antiporter, which is widely reported to support anti-oxidant defenses in vivo. xCT is therefore at the crossroads between two processes that are involved in schizophrenia: oxidative stress… read more here.
Keywords: schizophrenia; xct; antiporter; xct schizophrenia ... See more keywords
NCOA4-mediated ferroptosis conducive to EMT inhibition in colorectal cancer cells was achieved through the PI3K/AKT/mTOR pathway
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-23180-y
Abstract: The link of epithelial–mesenchymal transition (EMT) program with metastasis is well documented. However, the role of ROS in EMT process is self-contradictory. DpdtpA was a dithiocarbamate derivative (an iron chelator) that exhibits excellent growth and… read more here.
Keywords: colorectal cancer; xct; ferroptosis; emt ... See more keywords
X-ray computed tomography and additive manufacturing in medicine: a review
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Metrology and Quality Engineering"
DOI: 10.1051/ijmqe/2017015
Abstract: The use of X-ray computed tomography (XCT) with additive manufacture (AM) within a medical context is examined in this review. The seven AM process families and various XCT scanning techniques are explained in brief, and… read more here.
Keywords: tomography additive; medicine; ray computed; computed tomography ... See more keywords
Molecular dynamic approach in the regulation of systemic XCT antiporter through biologically active molecules for ischemic stroke
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Simulation"
DOI: 10.1080/08927022.2023.2300422
Abstract: ABSTRACT The heterodimeric amino acid transporter systemic XCT plays a crucial role in redox balance regulation by facilitating L-cystine and L-glutamate import/export in a 1:1 ratio. Translating findings from preclinical to clinical contexts poses challenges… read more here.
Keywords: dynamic approach; approach regulation; xct; molecular dynamic ... See more keywords
Bovine herpesvirus 4-based vector delivering the full length xCT DNA efficiently protects mice from mammary cancer metastases by targeting cancer stem cells
Sign Up to like & getrecommendations! Published in 2018 at "OncoImmunology"
DOI: 10.1080/2162402x.2018.1494108
Abstract: ABSTRACT Despite marked advancements in its treatment, breast cancer is still the second leading cause of cancer death in women, due to relapses and distal metastases. Breast cancer stem cells (CSCs), are a cellular reservoir… read more here.
Keywords: vector; cancer stem; xct; cancer ... See more keywords
The effects of manual XCT focusing on extracted surface texture data
Sign Up to like & getrecommendations! Published in 2022 at "Surface Topography: Metrology and Properties"
DOI: 10.1088/2051-672x/ac552d
Abstract: X-Ray computed tomography, (XCT) has begun to prove itself as a valid method to quantify internal and external surface metrology of parts. However, the understanding of how a small change in the capture settings of… read more here.
Keywords: extracted surface; surface data; surface texture; xct ... See more keywords