High expression of cystine–glutamate antiporter xCT (SLC7A11) is an independent biomarker for epileptic seizures at diagnosis in glioma
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-018-2785-9
Abstract: Epileptic seizures are an important cause of morbidity in glioma patients. Substantial lines of evidence support the concept of the excitatory neurotransmitter glutamate being a crucial mediator of glioma-associated seizures. In gliomas, non-vesicular secretion of… read more here.
Keywords: xct expression; xct; glioma; expression ... See more keywords
Semi-quantitative distribution of excitatory amino acid (glutamate) transporters 1–3 (EAAT1-3) and the cystine-glutamate exchanger (xCT) in the adult murine spinal cord
Sign Up to like & getrecommendations! Published in 2020 at "Neurochemistry International"
DOI: 10.1016/j.neuint.2020.104811
Abstract: Proper glutamatergic neurotransmission requires a balance between glutamate release and removal. The removal is mainly catalyzed by the glutamate transporters EAAT1-3, while the glutamate-cystine exchanger (system xc- with specific subunit xCT) represents one of the… read more here.
Keywords: xct; glutamate transporters; glutamate; distribution ... See more keywords
xCT/SLC7A11 antiporter function inhibits HIV-1 infection.
Sign Up to like & getrecommendations! Published in 2021 at "Virology"
DOI: 10.1016/j.virol.2021.01.008
Abstract: Human macrophages are protected by intrinsic antiviral defenses that provide moderate protection against HIV-1 infection. Macrophages that do become infected can serve as long-lived reservoirs, to disseminate HIV-1 to CD4+ T cells. Infection of macrophages… read more here.
Keywords: hiv infection; xct; xct slc7a11; antiporter ... See more keywords
Implication of the glutamate–cystine antiporter xCT in schizophrenia cases linked to impaired GSH synthesis
Sign Up to like & getrecommendations! Published in 2017 at "NPJ Schizophrenia"
DOI: 10.1038/s41537-017-0035-3
Abstract: AbstractxCT is the specific chain of the cystine/glutamate antiporter, which is widely reported to support anti-oxidant defenses in vivo. xCT is therefore at the crossroads between two processes that are involved in schizophrenia: oxidative stress… read more here.
Keywords: schizophrenia; xct; antiporter; xct schizophrenia ... See more keywords
X-ray computed tomography and additive manufacturing in medicine: a review
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Metrology and Quality Engineering"
DOI: 10.1051/ijmqe/2017015
Abstract: The use of X-ray computed tomography (XCT) with additive manufacture (AM) within a medical context is examined in this review. The seven AM process families and various XCT scanning techniques are explained in brief, and… read more here.
Keywords: tomography additive; medicine; ray computed; computed tomography ... See more keywords
Bovine herpesvirus 4-based vector delivering the full length xCT DNA efficiently protects mice from mammary cancer metastases by targeting cancer stem cells
Sign Up to like & getrecommendations! Published in 2018 at "OncoImmunology"
DOI: 10.1080/2162402x.2018.1494108
Abstract: ABSTRACT Despite marked advancements in its treatment, breast cancer is still the second leading cause of cancer death in women, due to relapses and distal metastases. Breast cancer stem cells (CSCs), are a cellular reservoir… read more here.
Keywords: vector; cancer stem; xct; cancer ... See more keywords
The effects of manual XCT focusing on extracted surface texture data
Sign Up to like & getrecommendations! Published in 2022 at "Surface Topography: Metrology and Properties"
DOI: 10.1088/2051-672x/ac552d
Abstract: X-Ray computed tomography, (XCT) has begun to prove itself as a valid method to quantify internal and external surface metrology of parts. However, the understanding of how a small change in the capture settings of… read more here.
Keywords: extracted surface; surface data; surface texture; xct ... See more keywords
Finding fossils in Malapa breccia – medical CT scanning or micro-CT scanning?
Sign Up to like & getrecommendations! Published in 2017 at "South African Journal of Science"
DOI: 10.17159/sajs.2017/20170057
Abstract: Computed tomography (CT) imaging of fossils has revolutionised the field of palaeontology, allowing researchers to gain a better understanding of fossil anatomy, preservation and conservation. Micro focus X-ray computed tomography (I¼XCT) has been far more… read more here.
Keywords: lower energy; xct; energy; breccia ... See more keywords
Atorvastatin Induces Mitochondria-Dependent Ferroptosis via the Modulation of Nrf2-xCT/GPx4 Axis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.806081
Abstract: As one of the cornerstones of clinical cardiovascular disease treatment, statins have an extensive range of applications. However, statins commonly used have side reactions, especially muscle-related symptoms (SAMS), such as muscle weakness, pain, cramps, and… read more here.
Keywords: cell; atorvastatin induces; gpx4; atorvastatin ... See more keywords
Aged xCT-Deficient Mice Are Less Susceptible for Lactacystin-, but Not 1-Methyl-4-Phenyl-1,2,3,6- Tetrahydropyridine-, Induced Degeneration of the Nigrostriatal Pathway
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2021.796635
Abstract: The astrocytic cystine/glutamate antiporter system xc– (with xCT as the specific subunit) imports cystine in exchange for glutamate and has been shown to interact with multiple pathways in the brain that are dysregulated in age-related… read more here.
Keywords: induced degeneration; age; aged xct; mice ... See more keywords
The Styryl Benzoic Acid Derivative DC10 Potentiates Radiotherapy by Targeting the xCT-Glutathione Axis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.786739
Abstract: Metastatic tumors with moderate radiosensitivity account for most cancer-related deaths, highlighting the limitations of current radiotherapy regimens. The xCT-inhibitor sulfasalazine (SAS) sensitizes cancer cells to radiotherapy by blocking cystine uptake via the xCT membrane antiporter,… read more here.
Keywords: cancer; styryl benzoic; dc10; gsh synthesis ... See more keywords