Discovery of a Napabucasin PROTAC as an Effective Degrader of the E3 Ligase ZFP91.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.0c01897
Abstract: Napabucasin, undergoing multiple clinical trials, was reported to inhibit the signal transducer and transcription factor 3 (STAT3). To better elucidate its mechanism of action, we designed a napabucasin-based proteolysis targeting chimera (PROTAC), XD2-149 that resulted… read more here.
Keywords: discovery napabucasin; zfp91; xd2 149; ligase zfp91 ... See more keywords