Targeted knock-in mice expressing the oxidase-fixed form of xanthine oxidoreductase favor tumor growth
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DOI: 10.1038/s41467-019-12565-z
Abstract: Xanthine oxidoreductase has been implicated in cancer. Nonetheless, the role played by its two convertible forms, xanthine dehydrogenase (XDH) and oxidase (XO) during tumorigenesis is not understood. Here we produce XDH-stable and XO-locked knock-in (ki)… read more here.
Keywords: tumor; knock mice; xdh; growth ... See more keywords
Xylose fermentation efficiency of industrial Saccharomyces cerevisiae yeast with separate or combined xylose reductase/xylitol dehydrogenase and xylose isomerase pathways
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology for Biofuels"
DOI: 10.1186/s13068-019-1360-8
Abstract: BackgroundXylose isomerase (XI) and xylose reductase/xylitol dehydrogenase (XR/XDH) pathways have been extensively used to confer xylose assimilation capacity to Saccharomyces cerevisiae and tackle one of the major bottlenecks in the attainment of economically viable lignocellulosic… read more here.
Keywords: xylitol dehydrogenase; reductase xylitol; saccharomyces cerevisiae; xdh ... See more keywords
Xanthine dehydrogenase rewires metabolism and the survival of nutrient deprived lung adenocarcinoma cells by facilitating UPR and autophagic degradation
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DOI: 10.7150/ijbs.78948
Abstract: Xanthine dehydrogenase (XDH) is the rate-limiting enzyme in purine catabolism by converting hypoxanthine to xanthine and xanthine to uric acid. The altered expression and activity of XDH are associated with the development and prognosis of… read more here.
Keywords: inhibition; survival starved; starved luad; xdh ... See more keywords
C1QBP regulates apoptosis of renal cell carcinoma via modulating xanthine dehydrogenase (XDH) mediated ROS generation
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DOI: 10.7150/ijms.71703
Abstract: Background: Complement component 1 Q subcomponent binding protein (C1QBP) plays a vital role in the progression and metabolism of cancer. Studies have shown that xanthine dehydrogenase (XDH)-derived reactive oxygen species (ROS) accelerates tumor growth, and… read more here.
Keywords: c1qbp; renal cell; xanthine dehydrogenase; apoptosis renal ... See more keywords