Characterisation and antidiabetic utility of a novel hybrid peptide, exendin‐4/gastrin/xenin‐8‐Gln
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.07.027
Abstract: ABSTRACT Enteroendocrine derived hormones such as glucagon‐like‐peptide‐1 (GLP‐1), glucose‐dependent insulinotropic polypeptide (GIP), gastrin and xenin are known to exert complementary beneficial metabolic effects in diabetes. This study has assessed the biological activity and therapeutic utility… read more here.
Keywords: xenin; xenin gln; exendin gastrin; gastrin xenin ... See more keywords
Effects of an enzymatically stable C-terminal hexapseudopeptide fragment peptide of xenin-25, ψ-xenin-6, on pancreatic islet function and metabolism
Sign Up to like & getrecommendations! Published in 2019 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2019.110523
Abstract: Xenin-25 undergoes rapid enzyme metabolism following secretion. Early studies demonstrated bioactivity of a C-terminal hexapeptide fragment of xenin-25, namely xenin-6, which were enhanced through introduction of a reduced N-terminal peptide bond, to yield Ψ-xenin-6. The… read more here.
Keywords: stable terminal; xenin; metabolism; xenin xenin ... See more keywords