Odd Loop Regions of XenA and XenB Enzymes Modulate Their Interaction with Nitro-explosives Compounds and Provide Structural Support for Their Regioselectivity
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DOI: 10.1021/acs.jcim.9b00357
Abstract: The nitro-explosive compounds 2,4,6-trinitrotoluene, 2,4,6-trinitrophenol and 1,2,3- trinitroglycerol are persistent environmental contaminants. The presence of different functional groups in these molecules represents a great challenge to enzymatic catalysis. The chemical variety of these three substrates… read more here.
Keywords: reductase; regioselectivity; nitro; interaction ... See more keywords
Structural Factors That Determine the Activity of the Xenobiotic Reductase B Enzyme from Pseudomonas putida on Nitroaromatic Compounds
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DOI: 10.3390/ijms24010400
Abstract: Xenobiotic reductase B (XenB) catalyzes the reduction of the aromatic ring or nitro groups of nitroaromatic compounds with methyl, amino or hydroxyl radicals. This reaction is of biotechnological interest for bioremediation, the reuse of industrial… read more here.
Keywords: structural factors; xenobiotic reductase; activity; factors determine ... See more keywords