Mini‐patient‐derived xenograft assay based on microfluidic technology promises to be an effective tool for screening individualized chemotherapy regimens for advanced non‐small cell lung cancer
Sign Up to like & getrecommendations! Published in 2021 at "Cell Biology International"
DOI: 10.1002/cbin.11622
Abstract: Patient‐derived xenograft (PDX) assay has been widely used in preclinical research in patients with multidrug‐resistant lung cancer. One hundred patients with non‐small cell lung cancer (NSCLC) were divided into MiniPDX group and conventional group, with… read more here.
Keywords: chemotherapy; xenograft; group; lung cancer ... See more keywords
Comprehensive physiopathology and serum metabolomics for the evaluation of the influence mechanism of Qi deficiency on xenograft mouse models of liver cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of separation science"
DOI: 10.1002/jssc.202100260
Abstract: Traditional Chinese medicine believes that qi deficiency is an important pathogenesis and syndrome of liver cancer and thus is crucial in related research. However, the effect of qi deficiency on the occurrence and development of… read more here.
Keywords: metabolism; xenograft; deficiency; liver cancer ... See more keywords
Patient-Derived Xenograft and Mice Models in Esophageal Squamous Cell Carcinoma.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0377-2_11
Abstract: Mouse models are important in the study of pathogenesis, testing new treatment, and monitoring the progress of treatment in patients with esophageal squamous cell carcinoma (ESCC). The mice commonly used are immunosuppressed. The first category… read more here.
Keywords: esophageal squamous; xenograft; model; mice ... See more keywords
Human microdosing and mice xenograft data of AGM-130 applied to estimate efficacious doses in patients
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DOI: 10.1007/s00280-017-3373-y
Abstract: PurposeAGM-130 is a cyclin-dependent kinase inhibitor that exhibits dose-dependent efficacy in xenograft mouse models. During preclinical pharmacokinetic (PK) studies, mice and rats showed comparable PK parameters while dogs showed unusually high clearance (CL), which has… read more here.
Keywords: human microdosing; xenograft; agm 130; model ... See more keywords
The exosome secretion inhibitor neticonazole suppresses intestinal dysbacteriosis-induced tumorigenesis of colorectal cancer
Sign Up to like & getrecommendations! Published in 2019 at "Investigational New Drugs"
DOI: 10.1007/s10637-019-00759-7
Abstract: Colorectal cancer (CRC) is the most frequently encountered malignancy associated with the rectum or colon, and accumulating evidences have implicated intestinal dysbacteriosis (IDB, disruption of gut microbiome) and exosomes in the pathology of CRC. We… read more here.
Keywords: secretion; inhibitor neticonazole; xenograft; secretion inhibitor ... See more keywords
Acute myeloid leukemia xenograft success prediction: Saving time
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Hematology"
DOI: 10.1016/j.exphem.2017.12.002
Abstract: HIGHLIGHTS • Extracellular phenotype, apoptosis, or cell cycle profile at thawing cannot predict acute myeloid leukemia (AML) xenograft potential.• Leukemic long-term culture-initiating cell content distinguishes fast and delayed engraftment potential.• Defined here is a 1-week… read more here.
Keywords: myeloid leukemia; xenograft; xenograft success; acute myeloid ... See more keywords
Cytotoxic T Lymphocytes Regenerated from iPS Cells Have Therapeutic Efficacy in a Patient-Derived Xenograft Solid Tumor Model
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DOI: 10.1016/j.isci.2020.100998
Abstract: Summary Current adoptive T cell therapies conducted in an autologous setting are costly, time consuming, and depend on the quality of the patient's T cells. To address these issues, we developed a strategy in which… read more here.
Keywords: xenograft; therapeutic efficacy; cytotoxic lymphocytes; model ... See more keywords
Progestogens and PGRMC1-dependent breast cancer tumor growth: An in-vitro and xenograft study.
Sign Up to like & getrecommendations! Published in 2019 at "Maturitas"
DOI: 10.1016/j.maturitas.2019.01.015
Abstract: OBJECTIVES A few observational studies have suggested that progesterone and dydrogesterone may have a lower risk of breast cancer than other progestogens. In our earlier xenograft animal experiments, progesterone did not stimulate breast tumors. The… read more here.
Keywords: progesterone; study; tumor growth; dydrogesterone ... See more keywords
Establishment and characterization of uterine sarcoma and carcinosarcoma patient-derived xenograft models.
Sign Up to like & getrecommendations! Published in 2017 at "Gynecologic oncology"
DOI: 10.1016/j.ygyno.2017.06.005
Abstract: OBJECTIVE Uterine sarcomas (US) and carcinosarcomas (CS) are rare, aggressive cancers. The lack of reliable preclinical models hampers the search for new treatment strategies and predictive biomarkers. To this end, we established and characterized US… read more here.
Keywords: uterine sarcoma; xenograft; sarcoma carcinosarcoma; derived xenograft ... See more keywords
Identification of Parthenolide Dimers as Activators of Pyruvate Ki-nase M2 in Xenograft of Glioblastoma Multiforme in vivo.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.9b01328
Abstract: Herein we detail the discovery of a series of parthenolide dimers as activators of PKM2 and evaluation of their anti-GBM activities. The most promising compound 5 showed high potency to activate PKM2 with AC50 value… read more here.
Keywords: vivo; pkm2; xenograft; compound ... See more keywords
3D DESI-MS lipid imaging in a xenograft model of glioblastoma: a proof of principle
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DOI: 10.1038/s41598-020-73518-x
Abstract: Desorption electrospray ionisation mass spectrometry (DESI-MS) can image hundreds of molecules in a 2D tissue section, making it an ideal tool for mapping tumour heterogeneity. Tumour lipid metabolism has gained increasing attention over the past… read more here.
Keywords: heterogeneity; xenograft; desi imaging; lipid imaging ... See more keywords