International experience in the development of patient-derived xenograft models of diffuse intrinsic pontine glioma
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-018-03038-2
Abstract: PurposeDiffuse intrinsic pontine glioma is the most aggressive form of high grade glioma in children with no effective therapies. There have been no improvements in survival in part due poor understanding of underlying biology, and… read more here.
Keywords: xenograft models; intrinsic pontine; pontine glioma; development ... See more keywords
A cancer-specific anti-podocalyxin monoclonal antibody (60-mG2a-f) exerts antitumor effects in mouse xenograft models of pancreatic carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Biochemistry and Biophysics Reports"
DOI: 10.1016/j.bbrep.2020.100826
Abstract: Overexpression of podocalyxin (PODXL) is associated with progression, metastasis, and poor outcomes in several cancers. PODXL also plays an important role in the development of normal tissues. For antibody-based therapy to target PODXL-expressing cancers using… read more here.
Keywords: xenograft models; cancer specific; antibody; podxl ... See more keywords
Patient-derived xenograft models of neuroendocrine prostate cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer letters"
DOI: 10.1016/j.canlet.2021.11.004
Abstract: In recent years, patient-derived xenografts (PDXs) have attracted much attention as clinically relevant models for basic and translational cancer research. PDXs retain the principal histopathological and molecular heterogeneity of their donor tumors and remain stable… read more here.
Keywords: xenograft models; prostate cancer; derived xenograft; neuroendocrine prostate ... See more keywords
Isoform- and Phosphorylation-specific Multiplexed Quantitative Pharmacodynamics of Drugs Targeting PI3K and MAPK Signaling in Xenograft Models and Clinical Biopsies
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.mct-20-0566
Abstract: Ras/Raf/MEK/ERK (MAPK) and PI3K/AKT signaling pathways influence several cell functions involved in oncogenesis, making them attractive drug targets. We describe a novel multiplex immunoassay to quantitate isoform-specific phosphorylation of proteins in the PI3K/AKT and MAPK… read more here.
Keywords: xenograft models; phosphorylation; mapk; pi3k ... See more keywords
Abstract 4127: Niraparib is active against prostate xenograft models that are wild type or defective for DNA damage repair genes
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.am2020-4127
Abstract: Patients with metastatic prostate cancer may respond well to first- and second-generation androgen receptor (AR)-targeted therapies, but all will eventually experience disease progression, indicating a need for alternative therapies. A subset of these patients bears… read more here.
Keywords: prostate; xenograft models; cancer; prostate xenograft ... See more keywords
Abstract 1680: Characterization of sensitivity to single agents and combination treatments (VAC and VI) and development of acquired resistance in childhood rhabdomyosarcoma xenograft models
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1680
Abstract: For childhood rhabdomyosarcoma (RMS), a tumor demonstrating characteristics of skeletal muscle lineage, survival has not changed significantly in over two decades. In a recent high-risk clinical trial (ARST0431) 25% of patients progressed during 52 weeks… read more here.
Keywords: acquired resistance; sensitivity; xenograft models; resistance ... See more keywords
Abstract PS18-16: The complete estrogen receptor antagonist OP-1250 shrinks tumors in xenograft models and has favorable preclinical pharmacokinetic attributes
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Research"
DOI: 10.1158/1538-7445.sabcs20-ps18-16
Abstract: Antiestrogens are widely used to treat ER+, HER2- breast cancer however these may produce estrogen-like agonist effects in a cell and gene-specific manner. Furthermore, this partial agonism has been implicated in the development of tumor… read more here.
Keywords: xenograft models; tumors xenograft; complete estrogen; antagonist ... See more keywords
Patient-derived xenograft models in musculoskeletal malignancies
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-018-1487-6
Abstract: Successful oncological drug development for bone and soft tissue sarcoma is grossly stagnating. A major obstacle in this process is the lack of appropriate animal models recapitulating the complexity and heterogeneity of musculoskeletal malignancies, resulting… read more here.
Keywords: xenograft models; musculoskeletal malignancies; derived xenograft; patient derived ... See more keywords
Difference in morphology and interactome profiles between orthotopic and subcutaneous gastric cancer xenograft models
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Toxicologic Pathology"
DOI: 10.1293/tox.2018-0020
Abstract: In xenograft models, orthotopic (ORT) engraftment is thought to provide a different tumor microenvironment compared with subcutaneous (SC) engraftment. We attempted to characterize the biological difference between OE19 (adenocarcinoma of the gastroesophageal junction) SC and… read more here.
Keywords: xenograft models; difference; analysis; cancer ... See more keywords
Short-Term Circulating Tumor Cell Dynamics in Mouse Xenograft Models and Implications for Liquid Biopsy
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2020.601085
Abstract: Motivation Circulating tumor cells (CTCs) are widely studied using liquid biopsy methods that analyze fractionally-small peripheral blood (PB) samples. However, little is known about natural fluctuations in CTC numbers that may occur over short timescales… read more here.
Keywords: xenograft models; ctc numbers; liquid biopsy; circulating tumor ... See more keywords
Imaging Immune Cells Using Fc Domain Probes in Mouse Cancer Xenograft Models
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14020300
Abstract: Simple Summary The immune system responds to abnormal cell growth by sending immune cells to kill them. The immune cell response is very important since it can usually stop abnormal cells from growing and spreading.… read more here.
Keywords: cell; xenograft models; immune cells; response ... See more keywords