Xenograft tumors derived from malignant pleural effusion of the patients with non-small-cell lung cancer as models to explore drug resistance
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Communications"
DOI: 10.1186/s40880-018-0284-1
Abstract: BackgroundNon-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutations or anaplastic lymphoma kinase (ALK) fusions show dramatic responses to specific tyrosine kinase inhibitors (TKIs); however, after 10–12 months, secondary mutations arise that… read more here.
Keywords: drug resistance; alk; xenograft; xenograft tumors ... See more keywords
GLUT3/SLC2A3 Is an Endogenous Marker of Hypoxia in Prostate Cancer Cell Lines and Patient-Derived Xenograft Tumors
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DOI: 10.3390/diagnostics12030676
Abstract: The microenvironment of solid tumors is dynamic and frequently contains pockets of low oxygen levels (hypoxia) surrounded by oxygenated tissue. Indeed, a compromised vasculature is a hallmark of the tumor microenvironment, creating both spatial gradients… read more here.
Keywords: glut3 slc2a3; prostate; xenograft tumors; patient derived ... See more keywords
PTK7, a Catalytically Inactive Receptor Tyrosine Kinase, Increases Oncogenic Phenotypes in Xenograft Tumors of Esophageal Squamous Cell Carcinoma KYSE-30 Cells
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DOI: 10.3390/ijms23042391
Abstract: Protein tyrosine kinase 7 (PTK7), a catalytically defective receptor protein tyrosine kinase, is upregulated in tumor tissues and cell lines of esophageal squamous cell carcinoma (ESCC). We showed that PTK7 plays an oncogenic role in… read more here.
Keywords: cell; xenograft tumors; tyrosine kinase; kyse cells ... See more keywords