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   Articles with "xenophagy" as a keyword



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A Mycobacterium tuberculosis surface protein recruits ubiquitin to trigger host xenophagy

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recommendations! Published in 2019 at "Nature Communications"

DOI: 10.1038/s41467-019-09955-8

Abstract: Ubiquitin-mediated xenophagy, a type of selective autophagy, plays crucial roles in host defense against intracellular pathogens including Mycobacterium tuberculosis (Mtb). However, the exact mechanism by which host ubiquitin targets invaded microbes to trigger xenophagy remains… read more here.

Keywords: mycobacterium tuberculosis; surface protein; host; xenophagy ... See more keywords
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Chemical modulation of SQSTM1/p62-mediated xenophagy that targets a broad range of pathogenic bacteria

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recommendations! Published in 2022 at "Autophagy"

DOI: 10.1080/15548627.2022.2054240

Abstract: ABSTRACT The N-degron pathway is a proteolytic system in which the N-terminal degrons (N-degrons) of proteins, such as arginine (Nt-Arg), induce the degradation of proteins and subcellular organelles via the ubiquitin-proteasome system (UPS) or macroautophagy/autophagy-lysosome… read more here.

Keywords: chemical modulation; xenophagy; sqstm1 p62; broad range ... See more keywords
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Group A Streptococcus Induces LAPosomes via SLO/β1 Integrin/NOX2/ROS Pathway in Endothelial Cells That Are Ineffective in Bacterial Killing and Suppress Xenophagy

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recommendations! Published in 2019 at "mBio"

DOI: 10.1128/mbio.02148-19

Abstract: Our previous reports showed that the LC3-associated GAS-containing single membrane vacuoles are inefficient for bacterial clearance in endothelial cells, which may result in bacteremia. However, the characteristics and the induction mechanisms of these LC3-positive vacuoles… read more here.

Keywords: gas; nox2 ros; membrane; endothelial cells ... See more keywords
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Resveratrol-Induced Xenophagy Promotes Intracellular Bacteria Clearance in Intestinal Epithelial Cells and Macrophages

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recommendations! Published in 2019 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2018.03149

Abstract: Autophagy is a lysosomal degradation process that contributes to host immunity by eliminating invasive pathogens and the modulating inflammatory response. Several infectious and immune disorders are associated with autophagy defects, suggesting that stimulation of autophagy… read more here.

Keywords: intracellular bacteria; intestinal epithelial; resveratrol; epithelial cells ... See more keywords
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Locally generated C3 regulates the clearance of Toxoplasma gondii by IFN-γ-primed macrophage through regulation of xenophagy

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recommendations! Published in 2022 at "Frontiers in Microbiology"

DOI: 10.3389/fmicb.2022.944006

Abstract: Exogenous pathogen infection can induce autophagy in cells. Autophagy is essential for cell survival, development, and homeostasis. It not only regulates cell defense and stress, but also has a close relationship with innate and adaptive… read more here.

Keywords: xenophagy; microscopy; gondii; regulation ... See more keywords