Comparison between slow and rapid freezing for adrenal gland cryopreservation and xenotransplantation.
Sign Up to like & getrecommendations! Published in 2021 at "Cryobiology"
DOI: 10.1016/j.cryobiol.2021.07.011
Abstract: The aim of our study was to examine whether slow or rapid cryopreservation of adrenal xenografts affected xenotransplant outcome. Adrenal xenografts were got from newborn piglets ( read more here.
Keywords: xenotransplantation group; cryopreservation xenotransplantation; group; xenotransplantation ... See more keywords
“You cannot stay in the laboratory forever”*: Taking pig kidney xenotransplantation from the laboratory to the clinic
Sign Up to like & getrecommendations! Published in 2021 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2021.103562
Abstract: Progress in life-supporting kidney transplantation in the genetically-engineered pig-to-nonhuman primate model has been encouraging, with pig kidneys sometimes supporting life for > 1 year. What steps need to be taken by (i) the laboratory team,… read more here.
Keywords: pig kidney; stay laboratory; xenotransplantation; laboratory forever ... See more keywords
Attitude Toward Organ and Tissue Xenotransplantation Questionnaire (PCID-XENOTx-Ríos): Characteristics and Psychometric Properties of the Validation in Spanish-Speaking Populations.
Sign Up to like & getrecommendations! Published in 2018 at "Transplantation proceedings"
DOI: 10.1016/j.transproceed.2018.02.173
Abstract: INTRODUCTION Making xenotransplantation socially acceptable is the first step in working toward the promotion of this potential therapy option for providing transplant organs. However, most of the questionnaires used for this task are not validated.… read more here.
Keywords: organ tissue; questionnaire; xenotransplantation; pcid xenotx ... See more keywords
Aspects of histocompatibility testing in xenotransplantation.
Sign Up to like & getrecommendations! Published in 2021 at "Transplant immunology"
DOI: 10.1016/j.trim.2021.101409
Abstract: Xenotransplantation, using genetically-modified pigs for clinical organ transplantation, is a solution to the organ shortage. The biggest barrier to clinical implementation is the antigenicity of pig cells. Humans possess preformed antibody to pig cells that… read more here.
Keywords: pig; aspects histocompatibility; xenotransplantation; pig cells ... See more keywords
Generation and use of a humanized bone-marrow-ossicle niche for hematopoietic xenotransplantation into mice
Sign Up to like & getrecommendations! Published in 2017 at "Nature Protocols"
DOI: 10.1038/nprot.2017.088
Abstract: Xenotransplantation is frequently used to study normal and malignant hematopoiesis of human cells. However, conventional mouse xenotransplantation models lack essential human-specific bone-marrow (BM)-microenvironment-derived survival, proliferation, and self-renewal signals for engraftment of normal and malignant blood… read more here.
Keywords: niche; generation; xenotransplantation; marrow ... See more keywords
Risk of pathogenic virus transmission by somatic cell nuclear transfer: implications for xenotransplantation
Sign Up to like & getrecommendations! Published in 2022 at "Biology of Reproduction"
DOI: 10.1093/biolre/ioac120
Abstract: Abstract Using somatic cell nuclear transfer for the generation of cloned and transgenic animals bears the risk of transmission of viruses, either by the oocyte or by the introduced donor cell. There is evidence that… read more here.
Keywords: cell; nuclear transfer; transmission; somatic cell ... See more keywords
Attitude of the Chronic Kidney Disease Patients Toward Xenotransplantation of Organs
Sign Up to like & getrecommendations! Published in 2018 at "Transplantation"
DOI: 10.1097/01.tp.0000543729.26735.74
Abstract: Background Although xenotransplantation is still in an experimental phase, it is presented herein as a possible solution to the organ shortage. However, there are scarce data concerning how the chronic kidney disease patients would accept… read more here.
Keywords: disease patients; chronic kidney; donation; xenotransplantation ... See more keywords
Operational Tolerance in Xenotransplantation By Use of Regulatory T Cells with a SLA-specific Chimeric Antigen Receptor
Sign Up to like & getrecommendations! Published in 2018 at "Transplantation"
DOI: 10.1097/01.tp.0000543734.57229.97
Abstract: Organ shortage is currently the biggest hurdle in the successful treatment of patients with organ failure. Xenotransplantation, using porcine cells, tissues and organs may be one of the ways to avoid the growing organ shortage.… read more here.
Keywords: tolerance; regulatory cells; xenotransplantation; sla specific ... See more keywords
The science of xenotransplantation for nephrologists
Sign Up to like & getrecommendations! Published in 2022 at "Current Opinion in Nephrology and Hypertension"
DOI: 10.1097/mnh.0000000000000800
Abstract: Purpose of review The field of xenotransplantation has seen remarkable progress since its inception with recent preclinical trials in human recipients pushing kidney xenotransplantation one-step closer to clinical reality. In this review, we update practicing… read more here.
Keywords: xenotransplantation nephrologists; kidney; science xenotransplantation; nephrology ... See more keywords
Physiologic considerations of pig-to-human kidney xenotransplantation
Sign Up to like & getrecommendations! Published in 2022 at "Current Opinion in Nephrology and Hypertension"
DOI: 10.1097/mnh.0000000000000858
Abstract: Purpose of review The greatest challenge facing end-stage kidney disease (ESKD) patients is the scarcity of transplantable organs. Advances in genetic engineering that mitigate xenogeneic immune responses have made transplantation across species a potentially viable… read more here.
Keywords: pig human; human kidney; physiologic considerations; considerations pig ... See more keywords
Heart xenotransplantation
Sign Up to like & getrecommendations! Published in 2017 at "Current Opinion in Organ Transplantation"
DOI: 10.1097/mot.0000000000000461
Abstract: Purpose of review Cardiac xenotransplantation has entered an exciting era, marked by numerous considerable advances in the field, and continues to be of great interest because of its potential ability in ameliorating the current constraints… read more here.
Keywords: heart xenotransplantation; xenotransplantation; cardiac xenotransplantation;