Factor XIa Inhibitors in Anticoagulation Therapy: Recent Advances and Perspectives.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c02130
Abstract: Factor XIa (FXIa) in the intrinsic pathway of the coagulation process has been proven to be an effective and safe target for anticoagulant discovery with limited or no bleeding. Numerous small-molecule FXIa inhibitors (SMFIs) with… read more here.
Keywords: xia inhibitors; anticoagulation therapy; factor xia; discovery ... See more keywords
Factor XIa Inhibitors as New Anticoagulants.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b00173
Abstract: With the introduction of thrombin and factor Xa inhibitors to the oral anticoagulant market, significant improvements in both efficacy and safety have been achieved. Early clinical and preclinical data suggest that inhibitors of factor XIa… read more here.
Keywords: factor xia; chemistry; new anticoagulants; inhibitors new ... See more keywords