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   Articles with "xiap" as a keyword



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XIAP overexpression promotes bladder cancer invasion in vitro and lung metastasis in vivo via enhancing nucleolin‐mediated Rho‐GDIβ mRNA stability

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recommendations! Published in 2018 at "International Journal of Cancer"

DOI: 10.1002/ijc.31223

Abstract: Our recent studies demonstrate that X‐linked inhibitor of apoptosis protein (XIAP) is essential for regulating colorectal cancer invasion. Here, we discovered that RhoGDIβ was a key XIAP downstream effector mediating bladder cancer (BC) invasion in… read more here.

Keywords: cancer; xiap; cancer invasion; lung metastasis ... See more keywords
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Imatinib induces autophagy via upregulating XIAP in GIST882 cells.

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recommendations! Published in 2017 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2017.05.096

Abstract: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms originating from the gastrointestinal tract with gain of function mutations in receptor tyrosine kinases KIT or platelet-derived growth factor receptor A (PDGFRA). The main effective… read more here.

Keywords: imatinib induced; xiap; resistance; gist882 cells ... See more keywords
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ASPP2 enhances chemotherapeutic sensitivity through the down-regulation of XIAP expression in a p53 independent manner in hepatocellular carcinoma.

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recommendations! Published in 2019 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2018.11.181

Abstract: Apoptosis stimulated protein of p53-2 (ASPP2) induces the transcription of p53-targeted genes to stimulates its pro-apoptosis function. The poor chemotherapeutic sensitivity is associated with the decreased ASPP2 expression in many human cancers. Here, multiple genes… read more here.

Keywords: hepatocellular carcinoma; sensitivity; xiap expression; xiap ... See more keywords
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microRNA-137 promotes apoptosis in ovarian cancer cells via the regulation of XIAP

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recommendations! Published in 2017 at "British Journal of Cancer"

DOI: 10.1038/bjc.2016.379

Abstract: Background:microRNAs (miRNAs) have regulatory roles in various cellular processes, including apoptosis. Recently, X-linked inhibitor of apoptosis protein (XIAP) has been reported to be dysregulated in epithelial ovarian cancer (EOC). However, the mechanism underlying this dysregulation… read more here.

Keywords: mir 137; apoptosis; xiap; ovarian cancer ... See more keywords
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Molecular basis of SMAC-XIAP binding and the effect of electrostatic polarization

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recommendations! Published in 2020 at "Journal of Biomolecular Structure and Dynamics"

DOI: 10.1080/07391102.2020.1713892

Abstract: Abstract X-chromosome-linked inhibitor of apoptosis (XIAP) inhibits cell apoptosis. Overexpression of XIAP is widely found in human cancers. Second mitochondria-derived activator of caspase (SMAC) protein inhibits XIAP through binding with Baculovirus Inhibitor of apoptosis protein… read more here.

Keywords: protein; xiap binding; xiap; electrostatic polarization ... See more keywords
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LncRNA SNHG12 in extracellular vesicles derived from carcinoma-associated fibroblasts promotes cisplatin resistance in non-small cell lung cancer cells

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recommendations! Published in 2022 at "Bioengineered"

DOI: 10.1080/21655979.2021.2018099

Abstract: ABSTRACT Non-small-cell lung cancer (NSCLC) is defined as the most universally diagnosed class of lung cancer. Cisplatin (DDP) is an effective drug for NSCLC, but tumors are prone to drug resistance. The current study set… read more here.

Keywords: xiap; nsclc cells; resistance; lncrna snhg12 ... See more keywords
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Down-regulated HSA_circ_0003528 inhibits hepatocellular carcinoma aggressiveness via the miR-212-3p/XIAP axis

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recommendations! Published in 2022 at "Bioengineered"

DOI: 10.1080/21655979.2022.2066046

Abstract: ABSTRACT Hepatocellular carcinoma (HCC) is characterized by a high mortality rate. Dysregulated circular RNAs (circRNAs) play a vital role in HCC. We aimed to study the role of circ_0003528 in HCC and its fundamental molecular… read more here.

Keywords: hepatocellular carcinoma; xiap; hcc; circ 0003528 ... See more keywords
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MicroRNA‐130a regulates neurological deficit and angiogenesis in rats with ischaemic stroke by targeting XIAP

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recommendations! Published in 2020 at "Journal of Cellular and Molecular Medicine"

DOI: 10.1111/jcmm.15732

Abstract: MicroRNAs (miRNAs) have already been proposed to be implicated in the development of ischaemic stroke. We aim to investigate the role of miR‐130a in the neurological deficit and angiogenesis in rats with ischaemic stroke by… read more here.

Keywords: deficit angiogenesis; xiap; ischaemic stroke; mir 130a ... See more keywords
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Combined inhibition of XIAP and autophagy induces apoptosis and differentiation in acute myeloid leukaemia.

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recommendations! Published in 2023 at "Journal of cellular and molecular medicine"

DOI: 10.1111/jcmm.17765

Abstract: Perturbations in autophagy, apoptosis and differentiation have greatly affected the progression and therapy of acute myeloid leukaemia (AML). The role of X-linked inhibitor of apoptosis (XIAP)-related autophagy remains unclear in AML therapeutics. Here, we found… read more here.

Keywords: inhibition xiap; xiap; apoptosis differentiation; autophagy ... See more keywords
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USP47 deubiquitylates Groucho/TLE to promote Wnt–β-catenin signaling

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recommendations! Published in 2023 at "Science Signaling"

DOI: 10.1126/scisignal.abn8372

Abstract: The Wnt–β-catenin signal transduction pathway is essential for embryonic development and adult tissue homeostasis. Wnt signaling converts TCF from a transcriptional repressor to an activator in a process facilitated by the E3 ligase XIAP. XIAP-mediated… read more here.

Keywords: xiap; wnt catenin; wnt; wnt signaling ... See more keywords
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XIAP Regulation by MNK Links MAPK and NFκB Signaling to Determine an Aggressive Breast Cancer Phenotype.

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recommendations! Published in 2018 at "Cancer research"

DOI: 10.1158/0008-5472.can-17-1667

Abstract: Hyperactivation of the NFκB pathway is a distinct feature of inflammatory breast cancer (IBC), a highly proliferative and lethal disease. Gene expression studies in IBC patient tissue have linked EGFR (EGFR/HER2)-mediated MAPK signaling to NFκB… read more here.

Keywords: mnk; breast cancer; mapk signaling; xiap ... See more keywords